Acquired Resistance to Poly (ADP-ribose) Polymerase Inhibitor Olaparib in BRCA2-Associated Prostate Cancer Resulting From Biallelic BRCA2 Reversion Mutations Restores Both Germline and Somatic Loss-of-Function Mutations

被引：49

作者：

Carneiro, Benedito A. ^{[1
]}

Collier, Katharine Ann ^{[1
]}

Nagy, Rebecca J. ^{[3
]}

Pamarthy, Sahithi ^{[1
]}

Sagar, Vinay ^{[1
]}

Fairclough, Stephen ^{[3
]}

Odegaard, Justin ^{[3
]}

Lanman, Richard B. ^{[3
]}

Costa, Ricardo ^{[1
]}

Taxter, Timothy ^{[1
]}

Kuzel, Timothy M. ^{[2
]}

Fan, Alice ^{[4
]}

Chae, Young Kwang ^{[1
]}

Cristofanilli, Massimo ^{[1
]}

Hussain, Maha H. ^{[1
]}

Abdulkadir, Sarki A. ^{[1
]}

Giles, Francis J. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, 233 E Super St,Olson Pavil,1st Floor, Chicago, IL 60611 USA

[2] Rush Univ, Med Ctr, Chicago, IL 60612 USA

[3] Guardant Hlth, Redwood City, CA USA

[4] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA

来源：

JCO PRECISION ONCOLOGY | 2018年 / 2卷

关键词：

DNA-REPAIR DEFECT; CELL-FREE DNA; SECONDARY MUTATIONS; MUTANT-CELLS; TUMOR DNA; HETEROGENEITY; HETEROZYGOSITY; THERAPY; GENE;

D O I：

10.1200/PO.17.00176

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：1 / 8

页数：8

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