Role of active nanoliposomes in the surface and bulk mechanical properties of hybrid hydrogels

被引：22

作者：

Kadri, R. ^{[1
]}

Bacharouch, J. ^{[1
]}

Elkhoury, K. ^{[1
]}

Ben Messaoud, G. ^{[1
]}

Kahn, C. ^{[1
]}

Desobry, S. ^{[1
]}

Linder, M. ^{[1
]}

Tamayol, A. ^{[2
]}

Francius, G. ^{[3
,4
]}

Mano, J. F. ^{[5
]}

Sanchez-Gonzalez, L. ^{[1
]}

Arab-Tehrany, E. ^{[1
]}

机构：

[1] Univ Lorraine, Lab Ingn Biomol, TSA 40602, F-54518 Vandoeuvre Les Nancy, France

[2] Univ Nebraska, Dept Mech & Mat Engn, Lincoln, NE 68508 USA

[3] Univ Lorraine, Lab Chim Phys & Microbiol Environm, UMR 7564, F-54601 Villers Les Nancy, France

[4] CNRS, Lab Chim Phys & Microbiol Environm, UMR 7564, F-54601 Villers Les Nancy, France

[5] Univ Aveiro, CICECO Aveiro Inst Mat, Dept Chem, P-3810193 Aveiro, Portugal

来源：

MATERIALS TODAY BIO | 2020年 / 6卷

关键词：

Liposomes; GelMA; Alginate; IPN hydrogels; Nanofunctionalization; NANOCOMPOSITE HYDROGELS; NETWORK; POLYSACCHARIDES; NANOPARTICLES; DRESSINGS; POLYMERS; MEDICINE;

D O I：

10.1016/j.mtbio.2020.100046

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nanoliposomes are widely used as delivery vehicles for active compounds. Nanoliposomes from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties of the hydrogels are studied both on the surface and through the thickness of the 3D network. The obtained composite hydrogels exhibited strong mechanical properties and a highly porous surface. The blend ratio, as well as the concentration of nanoliposomes, affects the properties of the hydrogels. Nanofunctionalized hydrogels induced keratinocyte growth. These advantageous characteristics may open up many applications of the developed hydrogels in drug delivery and tissue engineering.

引用

页数：10

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