Guidance of stem cell fate on 2D patterned surfaces

被引:135
作者
Kolind, Kristian [1 ]
Leong, Kam W. [2 ]
Besenbacher, Flemming [1 ,3 ]
Foss, Morten [1 ]
机构
[1] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark
[2] Duke Univ, Dept Biomed Engn, Durham, NC 27708 USA
[3] Aarhus Univ, Dept Phys & Astron, DK-8000 Aarhus C, Denmark
关键词
Stem cells; Mechanotransduction; Stem cell therapy; Tissue engineering; Stem cell niche; 2D surfaces; MARROW STROMAL CELLS; FOCAL ADHESIONS; NEURAL CELLS; DIFFERENTIATION; NANOSCALE; BIOMATERIALS; EXPRESSION; SIZE; PROLIFERATION; CYTOSKELETAL;
D O I
10.1016/j.biomaterials.2012.05.070
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Stem cells possess unique abilities as they can renew themselves for extended periods of time and have the capacity to differentiate into a variety of lineages. They hold promise for treating a plethora of diseases ranging from musculoskeletal defects to myocardial infarction and to neural disorders. Understanding how to control the fate decision of these cells to self-renew or differentiate is paramount in stem cell tissue engineering. Recently, significant progress has been made in guiding stem cell differentiation in vitro, and we are beginning to understand the complex interplay of factors that control their fate. Here, we highlight the recent approaches for guidance of stem cells through patterning of surfaces at the micro- and nanoscale. Particular attention is given to chemical patterning of substrates with adhesion ligands and physical patterning with a variety of topographical features. These surface-mediated biochemical and mechanical cues have proven influential in altering a wide range of stem cell phenotypes. This approach to guide or ultimately control stem cells by surface patterning has enormous potential implications in cell therapies and regenerative medicine. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码:6626 / 6633
页数:8
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