New flavane gallates isolated from the leaves of Plicosepalus curviflorus and their hypoglycemic activity

被引：24

作者：

Al-Taweel, Areej Mohammad ^{[1
]}

Perveen, Shagufta ^{[1
]}

Fawzy, Ghada Ahmed ^{[1
,2
]}

Alqasoumi, Saleh Ibrahim ^{[1
]}

El Tahir, Kamal E. H. ^{[3
]}

机构：

[1] King Saud Univ, Coll Pharm, Dept Pharmacogonosy, Riyadh 11451, Saudi Arabia

[2] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo 11562, Egypt

[3] King Saud Univ, Coll Pharm, Dept Pharmacol, Riyadh 11451, Saudi Arabia

来源：

FITOTERAPIA | 2012年 / 83卷 / 08期

关键词：

Plicosepalus curviflorus; Flavane gallates; Hypoglycemic activity; CYTOTOXIC ACTIVITIES; PLANTS;

D O I：

10.1016/j.fitote.2012.09.010

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new flavane gallates were isolated from the leaves of Plicosepalus curviflorus. The structure of the new compounds was established as 2S,3R-3.3',4'.5,7-pentahydroxyflavane-5-O-gallate (1) and 2S,3R-3,3',4',5,5',7-hexahydroxyflavane-4',5-di-O-gallate (2), respectively. In addition, seven known compounds (-)-catechin (3). quercetin (4), lupeol (5), beta-sitosterol (6), pomolic acid (7), beta-sitosterol 3-O-beta-D-glucopyranoside (8) and 4-methoxycinnamic acid (9) were reported for the first time from the genus Plicosepalus. Compounds 1.2 and 3 were investigated for their hypoglycemic activity and showed significant hypoglycemic activity in Swiss Albino mice. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1610 / 1615

页数：6

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