Synthesis of oxadiazoles on solid support

被引：69

作者：

Hébert, N ^{[1
]}

Hannah, AL ^{[1
]}

Sutton, SC ^{[1
]}

机构：

[1] Trega Biosci Inc, San Diego, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期

关键词：

oxadiazoles; solid phase synthesis; combinatorial chemistry;

D O I：

10.1016/S0040-4039(99)01826-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aliphatic and aromatic nitriles linked to solid support were converted to amide oximes, and cyclized to oxadiazoles using N-protected amino acid anhydrides. The amino protecting group was removed and the products acylated or sulfonylated on resin to provide combinatorial libraries of oxadiazoles. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8547 / 8550

页数：4

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