PURPOSE. To develop a surgical incisional technique that helps overcome incompetent sclerotomy closure previously reported in sutureless 25-gauge vitrectomy. DESIGN: Prospective interventional. case series report. METHODS: We performed this surgical technique in 12 eyes of 12 consecutive patients scheduled for 25-gauge vitrectomy. The sclerotomy was created performing an oblique incision, a structural modification that helps the closure stay watertight once the cannulas are removed. RESULTS: This technical variation resulted in no intraoperative leakage after cannula removal in any of the 36 sclerotomies performed. CONCLUSIONS: Incision construction using this technique may resolve the reported sclerotomy leakage that in some cases had to be solved by suturing.