Advancements in the characterization of tissue resident memory T cells in skin disease

被引：5
作者：
Li, Lei [1 ,2 ,3 ]
Liu, PanPan [1 ,2 ,3 ]
Chen, Chao [1 ,2 ,3 ]
Yan, Bei [1 ,2 ,3 ]
Chen, Xiang [1 ,2 ,3 ]
Li, Jie [1 ,2 ,3 ]
Peng, Cong [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Dermatol, Xiangya Rd 87, Changsha 410008, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Hunan Key Lab Skin Canc & Psoriasis, Changsha, Peoples R China
[3] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
来源：
CLINICAL IMMUNOLOGY | 2022年 / 245卷
基金：
中国国家自然科学基金;
关键词：
Tissue resident memory T cells; Psoriasis; Melanoma; Autoimmune skin diseases; Tumor immunity; FIXED DRUG ERUPTION; CUTTING EDGE; TGF-BETA; EXPRESSION; DIFFERENTIATION; INFECTION; INFLAMMATION; PROGRAMS; SURVIVAL; SUBSETS;
D O I：
10.1016/j.clim.2022.109183
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The newly discovered subset of memory T cells, tissue resident memory T (TRM) cells, reside in peripheral tissues for a long time, contributing to a rapid immune response and constituting the first line of defense when path-ogens invade cells. Tissue resident memory T cells have unique transcriptome characteristics, and their presence in peripheral tissues is regulated by many factors. TRM cells residing in different tissues often express different surface markers. In addition to CD8+ and CD4+ T cells, which are the best-characterized T cells, Treg cells and various innate T cells can reside in nonlymphoid tissues. Many recent studies have shown that tissue resident memory T cells play indispensable roles in tumor immunity and allergic diseases. This paper reviews the dif-ferentiation, regulation, variety and function of TRM cells and the roles they play in skin diseases, including cutaneous melanoma and psoriasis.
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页数：11
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