Diabetic Macular Edema: Pathogenesis and Treatment

被引：399

作者：

Bhagat, Neelakshi ^{[1
]}

Grigorian, Ruben A. ^{[1
]}

Tutela, Arthur ^{[1
]}

Zarbin, Marco A. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Inst Ophthalmol & Visual Sci, Newark, NJ 07103 USA

来源：

SURVEY OF OPHTHALMOLOGY | 2009年 / 54卷 / 01期

关键词：

AGEs; angiotensin II; blood retinal barrier; clinically significant macular edema; diabetic macular edema; intravitreal steroid injection; laser photocoagulation; leukostasis; micropulse sub-threshold laser; OCT; PEDF; PKC; RAGE; retinal thickness analyzer; steroids; vasoactive factors; VEGF; vitrectomy; vitreoretinal interface; ENDOTHELIAL GROWTH-FACTOR; BLOOD-RETINAL BARRIER; OPTICAL COHERENCE TOMOGRAPHY; PROTEIN-KINASE-C; ARGON-LASER PHOTOCOAGULATION; GLYCATION END-PRODUCTS; EPITHELIUM-DERIVED FACTOR; CONVERTING ENZYME-INHIBITION; INTRAVITREAL TRIAMCINOLONE ACETONIDE; INTERCELLULAR-ADHESION MOLECULE-1;

D O I：

10.1016/j.survophthal.2008.10.001

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Diabetic macular edema is a major cause of visual impairment. The pathogenesis of macular edema appears to be multifactorial. Laser photocoagulation is the standard of care for macular edema. However, there are cases that are not responsive to laser therapy. Several therapeutic options have been proposed for the treatment of this condition. In this review we discuss several factors and mechanisms implicated in the etiology of macular edema (vasoactive factors, biochemical pathways, anatomical abnormalities). It seems that combined pharmacologic and surgical therapy may be the best approach for the management of macular edema in diabetic patients. (Surv Ophthalmol 54:1-32, 2009. (C) 2009 Elsevier Inc. All rights reserved.)

引用

页码：1 / 32

页数：32

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