One pot synthesis using supported reagents system KSCN/SiO2-RNH3OAc/Al2O3:: synthesis of 2-aminothiazoles and N-allylthioureas

被引：66

作者：

Aoyama, T ^{[1
]}

Murata, S

Arai, I

Araki, N

Takido, T

Suzuki, Y

Kodomari, M

机构：

[1] Nihon Univ, Coll Sci & Technol, Dept Mat & Appl Chem, Chiyoda Ku, Tokyo 1018308, Japan

[2] Shibaura Inst Technol, Dept Appl Chem, Minato Ku, Tokyo 1088548, Japan

来源：

TETRAHEDRON | 2006年 / 62卷 / 14期

关键词：

thiazoles; thioureas; one pot process;

D O I：

10.1016/j.tet.2006.01.075

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method has been developed for the synthesis of 2-aminothiazoles and N-allylthioureas from commercially available materials in one pot by using a supported reagents system, KSCN/SiO2-RNH3OAc/Al2O3, in which alpha-halo ketone reacts first KSCN/SiO2 and the product, alpha.-thiocyanatoketone, reacts with RNH3OAc/Al2O3 to give the final product, 2-aminothiazoles, in good yield and allyl bromide reacts with KSCN/SiO2 and the product, allyl isothiocyanate, reacts with RNH3OAc/Al2O3 to give N-allylthiourea. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3201 / 3213

页数：13

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