Cytotoxic Xenicane Diterpenes from the Brown Alga Padina pavonia (L.) Gaill.

被引：24

作者：

Awad, Nagwa E. ^{[1
]}

Selim, Mohamed A. ^{[2
]}

Metawe, Hemaia M. ^{[1
]}

Matloub, Azza A. ^{[1
]}

机构：

[1] Natl Res Ctr, Dept Pharmacognosy, Cairo, Egypt

[2] Fac Pharm, Dept Pharmacognosy, Cairo, Egypt

来源：

PHYTOTHERAPY RESEARCH | 2008年 / 22卷 / 12期

关键词：

marine brown algae; Padina pavonia; xenicane diterpenes; antitumor activity;

D O I：

10.1002/ptr.2532

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Column chromatography of the hexane fraction of a methanol extract of Padina pavonia (L.) Gaill. collected from the Red Sea at Hurghada, Egypt yielded 18,19-epoxyxenic-19-methoxy-18-hydroxy-4-acetoxy-6,9,13-triene (1) and 18,19-epoxyxenic-18,19-dimethoxy-4-hydroxy-6,9,13-triene (2). The isolated compounds have various antitumor activities against lung carcinoma (H460) and liver carcinoma (HepG2) human cell lines (in vitro). Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：1610 / 1613

页数：4

共 30 条

[1]

ABDELFATTAH AF, 1977, PHYTOCHEMISTRY, V16, P939

[2] BIOACTIVE DITERPENOIDS ISOLATED FROM DILOPHUS-LIGULATUS [J].