Rationale, Design, and Baseline Characteristics of the Prospective Japan Acute Myocardial Infarction Registry (JAMIR)

被引：25

作者：

Honda, Satoshi ^{[1
,21
]}

Nishihira, Kensaku ^{[1
,21
]}

Kojima, Sunao ^{[2
,20
]}

Takegami, Misa ^{[3
,21
]}

Asaumi, Yasuhide ^{[1
,21
]}

Suzuki, Makoto ^{[4
,12
]}

Kosuge, Masami ^{[5
,13
]}

Takahashi, Jun ^{[6
,11
]}

Sakata, Yasuhiko ^{[6
,11
]}

Takayama, Morimasa ^{[4
,12
]}

Sumiyoshi, Tetsuya ^{[4
,12
]}

Ogawa, Hisao ^{[1
,21
]}

Kimura, Kazuo ^{[5
,13
]}

Yasuda, Satoshi ^{[1
,21
]}

Takenaka, Takashi ^{[7
]}

Tomita, Hirofumi ^{[8
]}

Yokoyama, Hiroaki ^{[8
]}

Ito, Tomonori ^{[9
]}

Ishida, Masaru ^{[9
]}

Koeda, Yorihiko ^{[9
]}

Watanabe, Masafumi ^{[10
]}

Watanabe, Tetsu ^{[10
]}

Toshima, Taku ^{[10
]}

Shimokawa, Hiroaki ^{[11
]}

Hao, Kiyotaka ^{[11
]}

Ebina, Toshiaki ^{[13
]}

Suzuki, Hiroshi ^{[14
]}

Maeda, Atsuo ^{[14
]}

Ito, Masaaki ^{[15
]}

Kurita, Tairo ^{[15
]}

Masuda, Jun ^{[15
]}

Tanigawa, Takashi ^{[16
]}

Higaki, Jitsuo ^{[17
]}

Nishimura, Kazuhisa ^{[17
]}

Takahashi, Naohiko ^{[18
]}

Akioka, Hidefumi ^{[18
]}

Kawano, Kyoko ^{[18
]}

Maemura, Koji ^{[19
]}

Koide, Yuji ^{[19
]}

Kojima, Sunao ^{[2
,20
]}

Tsujita, Kenichi ^{[20
]}

Miyamoto, Yoshihiro ^{[21
]}

Nakao, Yoko ^{[21
]}

Nakajima, Hiroshi ^{[22
]}

Yamaguchi, Kenji ^{[23
]}

Makino, Takao ^{[24
]}

Kanno, Daitarou ^{[25
]}

Omoto, Yasuhiro ^{[26
]}

Hotta, Daisuke ^{[27
]}

Sato, Toshiya ^{[28
]}

机构：

[1] Natl Cerebral & Cardiovasc Ctr, Dept Cardiovasc Med, 5-7-1 Fujishiro Dai, Suita, Osaka 5658565, Japan

[2] Kawasaki Med Sch, Dept Gen Internal Med 3, Okayama, Japan

[3] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Med & Epidemiol Informat, Osaka, Japan

[4] Sakakibara Heart Inst, Dept Cardiol, Fuchu, Tokyo, Japan

[5] Yokohama City Univ, Dept Cardiovasc Med, Med Ctr, Yokohama, Kanagawa, Japan

[6] Tohoku Univ, Dept Cardiovasc Med, Sendai, Miyagi, Japan

[7] Hokkaido Med Ctr, Sapporo, Hokkaido, Japan

[8] Hirosaki Univ, Hirosaki, Aomori, Japan

[9] Iwate Med Univ, Morioka, Iwate, Japan

[10] Yamagata Univ, Yamagata, Japan

[11] Tohoku Univ, Sendai, Miyagi, Japan

[12] Sakakibara Heart Inst, Fuchu, Tokyo, Japan

[13] Yokohama City Univ Med, Yokohama, Kanagawa, Japan

[14] Showa Univ, Fujigaoka Hosp, Yokohama, Kanagawa, Japan

[15] Mie Univ Hosp, Tsu, Mie, Japan

[16] Matsuzaka Cent Gen Hosp, Matsuzaka, Mie, Japan

[17] Ehime Univ Hosp, Toon, Japan

[18] Oita Univ, Oita, Japan

[19] Nagasaki Univ, Nagasaki, Japan

[20] Kumamoto Univ, Kumamoto, Japan

[21] Natl Cerebral & Cardiovasc Ctr, Suita, Osaka, Japan

[22] Nagasaki Harbor Med Ctr, Nagasaki, Japan

[23] Isahaya Gen Hosp, Nagasaki, Japan

[24] Sapporo City Gen Hosp, Sapporo, Hokkaido, Japan

[25] Sapporo Cardiovasc Clin, Sapporo, Hokkaido, Japan

[26] Teine Keijinkai Hosp, Sapporo, Hokkaido, Japan

[27] Hokkaido Cardiol Hosp, Sapporo, Hokkaido, Japan

[28] Sapporo Kosei Gen Hosp, Sapporo, Hokkaido, Japan

[29] Nippon Med Sch, Musashi Kosugi Hosp, Tokyo, Japan

[30] Ayase Heart Hosp, Ayase, Kanagawa, Japan

[31] Tokyo Metropolitan Hiroo Gen Hosp, Tokyo, Japan

[32] Nippon Med Coll Hosp, Tokyo, Japan

[33] Tokyo Saiseikai Cent Hosp, Tokyo, Japan

[34] Tokyo Med Ctr, Tokyo, Japan

[35] St Lukes Int Hosp, Tokyo, Japan

[36] Edogawa Hosp, Tokyo, Japan

[37] Kyorin Univ Hosp, Mitaka, Tokyo, Japan

[38] Nihon Univ, Itabashi Hosp, Tokyo, Japan

[39] Toho Univ, Omori Med Ctr, Omori, Japan

[40] Mitsui Mem Hosp, Tokyo, Japan

[41] Tokyo Metropolitan Tama Med Ctr, Tokyo, Japan

[42] Disaster Med Ctr, Tachikawa, Tokyo, Japan

[43] Musashino Red Cross Hosp, Musashino, Tokyo, Japan

[44] NTT Med Ctr, Tokyo, Japan

[45] Oume Municipal Gen Hosp, Ome, Japan

[46] Oghikubo Hosp, Tokyo, Japan

[47] Teikyo Univ Hosp, Tokyo, Japan

[48] Fratern Mem Hosp, Tokyo, Japan

[49] Jikei Univ Hosp, Tokyo, Japan

[50] Tokyo Womens Med Univ Hosp, Tokyo, Japan

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 2019年 / 33卷 / 01期

关键词：

Acute myocardial infarction; Bleeding event; Antiplatelet therapy; ACUTE CORONARY SYNDROMES; CARDIOVASCULAR-DISEASE; EUROPEAN-SOCIETY; TASK-FORCE; CLOPIDOGREL; PRASUGREL; POLYMORPHISMS; MANAGEMENT; THROMBOLYSIS; EPIDEMIOLOGY;

D O I：

10.1007/s10557-018-6839-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BackgroundAntiplatelet therapy is a cornerstone of treatment following acute myocardial infarction (AMI). Recently, prasugrel, a new and potent antiplatelet agent, has been introduced in clinical practice. To date, however, real-world in-hospital and follow-up data in Japanese patients with AMI remain limited.ObjectivesTo examine ischemic and bleeding events in Japanese patients with AMI and the association between these events and antiplatelet therapy.MethodsThe Japan AMI Registry (JAMIR) is a multicenter, nationwide, prospective registry enrolling patients with AMI from 50 institutions. The inclusion criterion is spontaneous onset of AMI diagnosed based on either the universal definition or Monitoring Trends and Determinants in Cardiovascular disease (MONICA) criteria. The major exclusion criteria are hospital admission 24h after onset, no return of spontaneous circulation on admission following out-of-hospital cardiopulmonary arrest, and AMI as a complication of percutaneous coronary intervention or coronary artery bypass grafting. The primary end point of the study is the composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke. Major safety end points include major bleeding based on Thrombolysis in Myocardial Infarction (TIMI) criteria and type 3 or type 5 bleeding based on Bleeding Academic Research Consortium (BARC) criteria. Between December 2015 and May 2017, a total of 3411 patients (mean age 68.113.2years, 23.4% female) were enrolled in the study. Patients will be followed for 1year.Conclusions JAMIR will provide important information regarding contemporary practice patterns in the management of Japanese patients with AMI, their demographic and clinical characteristics, in-hospital and post-discharge outcomes, and how they are related to antiplatelet therapy.

引用

页码：97 / 103

页数：7

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