Cellular functions of long noncoding RNAs

被引：1099
|
作者：
Yao, Run-Wen [1 ]
Wang, Yang [1 ]
Chen, Ling-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Shanghai, Peoples R China
[2] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
来源：
NATURE CELL BIOLOGY | 2019年 / 21卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MESSENGER-RNAS; GENE-EXPRESSION; NUCLEAR-BODIES; X-CHROMOSOME; XIST RNA; ANTISENSE TRANSCRIPTION; CHROMATIN INTERACTIONS; COLORECTAL-CANCER; CERNA HYPOTHESIS; BINDING PROTEINS;
D O I：
10.1038/s41556-019-0311-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.
引用
收藏
页码：542 / 551
页数：10
相关论文
共 50 条
  • [1] Cellular functions of long noncoding RNAs
    Run-Wen Yao
    Yang Wang
    Ling-Ling Chen
    Nature Cell Biology, 2019, 21 : 542 - 551
  • [2] Cytoplasmic functions of long noncoding RNAs
    Noh, Ji Heon
    Kim, Kyoung Mi
    McClusky, Waverly G.
    Abdelmohsen, Kotb
    Gorospe, Myriam
    WILEY INTERDISCIPLINARY REVIEWS-RNA, 2018, 9 (03)
  • [3] Functions of long noncoding RNAs in the nucleus
    Yu, Bin
    Shan, Ge
    NUCLEUS, 2016, 7 (02) : 155 - 166
  • [4] Evolution and Functions of Long Noncoding RNAs
    Ponting, Chris P.
    Oliver, Peter L.
    Reik, Wolf
    CELL, 2009, 136 (04) : 629 - 641
  • [5] Neural functions of long noncoding RNAs in Drosophila
    Meixia Li
    Li Liu
    Journal of Comparative Physiology A, 2015, 201 : 921 - 926
  • [6] No-Nonsense Functions for Long Noncoding RNAs
    Nagano, Takashi
    Fraser, Peter
    CELL, 2011, 145 (02) : 178 - 181
  • [7] Neural functions of long noncoding RNAs in Drosophila
    Li, Meixia
    Liu, Li
    JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 2015, 201 (09): : 921 - 926
  • [8] The various regulatory functions of long noncoding RNAs in apoptosis, cell cycle, and cellular senescence
    Asl, Mohammad Heydarnezhad
    Khelejani, Faezeh Pasban
    Mahdavi, Seyedeh Zahra Bahojb
    Emrahi, Leila
    Jebelli, Asiyeh
    Mokhtarzadeh, Ahad
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2022, 123 (06) : 995 - 1024
  • [9] Small nucleolar RNAs: An abundant group of noncoding RNAs with diverse cellular functions
    Kiss, T
    CELL, 2002, 109 (02) : 145 - 148
  • [10] The nuclear functions of long noncoding RNAs come into focus
    Song, Zhenxing
    Lin, Jiamei
    Li, Zhengguo
    Huang, Chuan
    NON-CODING RNA RESEARCH, 2021, 6 (02): : 70 - 79
12345