Cellular functions of long noncoding RNAs

被引：1106
|
作者：
Yao, Run-Wen [1 ]
Wang, Yang [1 ]
Chen, Ling-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Univ Chinese Acad Sci, State Key Lab Mol Biol,Shanghai Key Lab Mol Andro, CAS Ctr Excellence Mol Cell Sci,Shanghai Inst Bio, Shanghai, Peoples R China
[2] ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China
来源：
NATURE CELL BIOLOGY | 2019年 / 21卷 / 05期
基金：
中国国家自然科学基金;
关键词：
MESSENGER-RNAS; GENE-EXPRESSION; NUCLEAR-BODIES; X-CHROMOSOME; XIST RNA; ANTISENSE TRANSCRIPTION; CHROMATIN INTERACTIONS; COLORECTAL-CANCER; CERNA HYPOTHESIS; BINDING PROTEINS;
D O I：
10.1038/s41556-019-0311-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential, are transcribed from the mammalian genome. They are emerging as important regulators in gene expression networks by controlling nuclear architecture and transcription in the nucleus and by modulating mRNA stability, translation and post-translational modifications in the cytoplasm. In this Review, we highlight recent progress in cellular functions of lncRNAs at the molecular level in mammalian cells.
引用
收藏
页码：542 / 551
页数：10
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