Decreased density of I-2-imidazoline receptors in the postmortem brains of heroin addicts

被引：42

作者：

Sastre, M ^{[1
]}

Ventayol, P ^{[1
]}

GarciaSevilla, JA ^{[1
]}

机构：

[1] UNIV ILLES BALEARS,DEPT BIOL FONAMAENTAL & CIENCIES SALUT,LAB NEUROFARMACOL,E-07071 PALMA DE MALLORCA,SPAIN

来源：

NEUROREPORT | 1996年 / 7卷 / 02期

关键词：

I-2-imidazoline receptors; H-3]idazoxan binding; imidazoline receptor proteins; Western immunoblot; heroin addiction; human and rat brain;

D O I：

10.1097/00001756-199601310-00032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE aim of this study was to quantitate imidazoline receptors in postmortem brains of heroin addicts who died of an opiate overdose. The density of I-2-imidazoline receptors ([H-3]idazoxan binding in the presence of adrenaline) and the immunoreactivity of the related 29/30 kDa imidazoline receptor protein were decreased (39% and 28%, respectively) in the frontal cortex. The density of brain I-2-imidazoline receptors was also decreased in heroin-dependent rats (27%). This novel finding indicates that opiate addiction induces down-regulation of I-2-imidazoline receptors in astrocytes, and presumably down-regulation of the functions associated with these receptors.

引用

页码：509 / 512

页数：4

共 25 条

[21]

Ruggiero D A, 1995, Ann N Y Acad Sci, V763, P208, DOI 10.1111/j.1749-6632.1995.tb32408.x

[22] MORPHINE SUPPRESSES DNA-SYNTHESIS IN CULTURED MURINE ASTROCYTES FROM CORTEX, HIPPOCAMPUS AND STRIATUM [J].

STIENEMARTIN, A ;

HAUSER, KF .

NEUROSCIENCE LETTERS, 1993, 157 (01) :1-3

[23]

ULIBARRI I, 1987, N-S ARCH PHARMACOL, V336, P530

[24]

WANG H, 1992, MOL PHARMACOL, V42, P792

[25] ENDOGENOUS OPIOID SYSTEMS REGULATE CELL-PROLIFERATION IN THE DEVELOPING RAT-BRAIN [J].

ZAGON, IS ;

MCLAUGHLIN, PJ .

BRAIN RESEARCH, 1987, 412 (01) :68-72

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