Decreased density of I-2-imidazoline receptors in the postmortem brains of heroin addicts

被引：41
作者：
Sastre, M [1 ]
Ventayol, P [1 ]
GarciaSevilla, JA [1 ]
机构：
[1] UNIV ILLES BALEARS,DEPT BIOL FONAMAENTAL & CIENCIES SALUT,LAB NEUROFARMACOL,E-07071 PALMA DE MALLORCA,SPAIN
来源：
NEUROREPORT | 1996年 / 7卷 / 02期
关键词：
I-2-imidazoline receptors; H-3]idazoxan binding; imidazoline receptor proteins; Western immunoblot; heroin addiction; human and rat brain;
D O I：
10.1097/00001756-199601310-00032
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE aim of this study was to quantitate imidazoline receptors in postmortem brains of heroin addicts who died of an opiate overdose. The density of I-2-imidazoline receptors ([H-3]idazoxan binding in the presence of adrenaline) and the immunoreactivity of the related 29/30 kDa imidazoline receptor protein were decreased (39% and 28%, respectively) in the frontal cortex. The density of brain I-2-imidazoline receptors was also decreased in heroin-dependent rats (27%). This novel finding indicates that opiate addiction induces down-regulation of I-2-imidazoline receptors in astrocytes, and presumably down-regulation of the functions associated with these receptors.
引用
收藏
页码：509 / 512
页数：4
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