Asymmetric Allylic Alkylation of Isatin-Derived Morita-Baylis-Hillman Carbonates with Nitroalkanes

被引：50
作者：
Chen, Guo-Ying
Zhong, Fangrui
Lu, Yixin [1 ]
机构：
[1] Natl Univ Singapore, Inst Life Sci, Dept Chem, Singapore 117543, Singapore
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 15期
关键词：
CONJUGATE ADDITION-ELIMINATION; ENANTIOSELECTIVE CONSTRUCTION; QUATERNARY STEREOCENTERS; PHOSPHINES SYNTHESIS; OXINDOLE ALKALOIDS; ACID-DERIVATIVES; SUBSTITUTION; ACETATES; CENTERS; HYDROGENATION;
D O I：
10.1021/ol301962e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A stereoselective allylic alkylation of isatin-derived Morita-Baylis-Hillman (MBH) carbonates with nitroalkanes has been developed. In the presence of 10 mol % beta-isocupreidine (beta-ICD), 3,3'-disubstituted oxindoles were prepared with moderate diastereoselectivities and excellent enantioselectivities.
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收藏
页码：3955 / 3957
页数：3
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