Coming up for air: HF-1 and mitochondrial oxygen consumption

被引：81

作者：

Simon, MC ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Abramson Family Canc Res Inst, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

来源：

CELL METABOLISM | 2006年 / 3卷 / 03期

关键词：

D O I：

10.1016/j.cmet.2006.02.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Hypoxic cells induce glycolytic enzymes; this HIF-1-mediated metabolic adaptation increases glucose flux to pyruvate and produces glycolytic ATP. Two papers in this issue of Cell Metabolism (Kim et al., 2006; Papandreou et al., 2006) demonstrate that HIF-1 also influences mitochondrial function, suppressing both the TCA cycle and respiration by inducing pyruvate dehydrogenase kinase 1 (PDK1). PDK1 regulation in hypoxic cells promotes cell survival.

引用

页码：150 / 151

页数：2

共 12 条

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