Sorafenib Is Effective in the Treatment of Pulmonary Veno-Occlusive Disease

被引：7
|
作者：
Kataoka, Masaharu [1 ,2 ]
Yanagisawa, Ryoji [1 ]
Fukuda, Keiichi [2 ]
Yoshino, Hideaki [1 ]
Satoh, Toru [1 ]
机构：
[1] Kyorin Univ, Sch Med, Div Cardiol, Dept Med, Mitaka, Tokyo 1818611, Japan
[2] Keio Univ, Sch Med, Dept Cardiol, Tokyo, Japan
来源：
CARDIOLOGY | 2012年 / 123卷 / 03期
关键词：
Hypertension; Imatinib; Pulmonary veno-occlusive disease; Side effect; Sorafenib; MULTIKINASE INHIBITOR; HYPERTENSION;
D O I：
10.1159/000342787
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The present study is the first report of the effectiveness of sorafenib in the treatment of pulmonary veno-occlusive disease (PVOD). A 66-year-old woman with PVOD was started on sorafenib. After 3 months of treatment with a maximum dosage of 400 mg/day sorafenib, there was an improvement in the patient's New York Heart Association (NYHA) functional class from IV to III. However, because of severe painful eruptions as a side effect of sorafenib, the patient stopped sorafenib and was started on imatinib instead. This treatment resulted in a worsening of the patient's NYHA class from III to IV, so sorafenib was restarted at a reduced dosage of 300 mg/day. The resumption of sorafenib was associated with clinical improvement, specifically NYHA class from IV to II and hemodynamic amelioration, and tolerable eruptions. In conclusion, sorafenib may be a potential therapeutic strategy for the treatment of PVOD. Copyright (C) 2012 S. Karger AG, Basel
引用
收藏
页码：172 / 174
页数：3
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