New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

被引：27
作者：
Lee, Y
Koo, H
Lim, YB
Lee, Y
Mo, HJ
Park, JS
机构：
[1] Seoul Natl Univ, Sch Chem & Mol Engn, Kwanak Ku, Seoul 151742, South Korea
[2] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94143 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 10期
关键词：
cationic lipid; low toxicity; gene transfer;
D O I：
10.1016/j.bmcl.2004.02.061
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by H-1 NMR. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2637 / 2641
页数：5
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