New challenges for pharmaceutical formulations and drug delivery systems characterization using isothermal titration calorimetry

被引：116

作者：

Bouchemal, Kawthar ^{[1
]}

机构：

[1] Univ Paris 11, Sch Pharm, CNRS, UMR 8612, F-92296 Chatenay Malabry, France

来源：

DRUG DISCOVERY TODAY | 2008年 / 13卷 / 21-22期

关键词：

D O I：

10.1016/j.drudis.2008.06.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Long viewed as the 'method of choice' for characterizing thermodynamics and stoichiometry of molecular interactions, with high sensitivity, isothermal titration calorimetry (ITC) has been applied to many areas of pharmaceutical analysis. This review highlights ITC employment to measure binding thermodynamics and their use for pharmaceutical formulations and drug delivery system characterization particularly cyclodextrin-guest interactions, investigation of micellar-based systems, polyelectrolytes, nucleic acid interactions with multivalent cations and the optimization of DNA targeting and delivery. Furthermore, the potential of ITC for the characterization of different functionalities carried by nanoparticles as well as their interaction with living systems was outlined.

引用

页码：960 / 972

页数：13

共 180 条

[51] Thermodynamic properties of association colloids [J].

Garidel, P ;

Hildebrand, A .

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, 2005, 82 (02) :483-489

[52] Thermodynamic characterization of bile salt aggregation as a function of temperature and ionic strength using isothermal titration calorimetry [J].

Garidel, P ;

Hildebrand, A ;

Neubert, R ;

Blume, A .

LANGMUIR, 2000, 16 (12) :5267-5275

[53] The interaction between nonionic dendrimers and surfactants - Electromotive force and microcalorimetry studies [J].

Ghoreishi, SM ;

Li, Y ;

Holzwarth, JF ;

Khoshdel, E ;

Warr, J ;

Bloor, DM ;

Wyn-Jones, E .

LANGMUIR, 1999, 15 (06) :1938-1944

[54] EMF and microcalorimetry studies associated with the binding of the cationic surfactants to neutral polymers [J].

Ghoreishi, SM ;

Fox, GA ;

Bloor, DM ;

Holzwarth, JF ;

Wyn-Jones, E .

LANGMUIR, 1999, 15 (17) :5474-5479

[55]

Goddard ED, 1993, INTERACTIONS SURFACT, P171

[56] Synthesis and characterization of a β-CD-alginate conjugate [J].

Gomez, Cesar G. ;

Chambat, Gerard ;

Heyraud, Alain ;

Villar, Marcelo ;

Auzely-Velty, Rachel .

POLYMER, 2006, 47 (26) :8509-8516

[57] Binding of oligoarginine to membrane lipids and heparan sulfate:: Structural and thermodynamic characterization of a cell-penetrating peptide [J].

Gonçalves, E ;

Kitas, E ;

Seelig, J .

BIOCHEMISTRY, 2005, 44 (07) :2692-2702

[58] Isothermal titration calorimetry studies on the binding of DNA bases and PNA base monomers to gold nanoparticles [J].

Gourishankar, A ;

Shukla, S ;

Ganesh, KN ;

Sastry, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (41) :13186-13187

[59] Surface-engineered nanoparticles for multiple ligand coupling [J].

Gref, R ;

Couvreur, P ;

Barratt, G ;

Mysiakine, E .

BIOMATERIALS, 2003, 24 (24) :4529-4537

[60] Characterization of β-lactoglobulin-chitosan interactions in aqueous solutions:: A calorimetry, light scattering, electrophoretic mobility and solubility study [J].

Guzey, D ;

McClements, DJ .

FOOD HYDROCOLLOIDS, 2006, 20 (01) :124-131

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