Isocyanide Insertion: De Novo Synthesis of Trifluoromethylated Phenanthridine Derivatives

被引：127

作者：

Cheng, Yuanzheng

Jiang, Heng

Zhang, Yan

Yu, Shouyun ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 21期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE CYCLIZATION; FLUORINE; ARYLATION; PYRIDINE; 6-(TRIFLUOROMETHYL)PHENANTHRIDINES; 2-ISOCYANOBIPHENYLS; HETEROARENES; INHIBITORS; ALKALOIDS; CATALYSIS;

D O I：

10.1021/ol4026827

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl)phenanthridine derivatives using ionic isocyanide insertion from biphenyl isocyanide derivatives and Umemoto's reagent. These reactions were promoted only by inorganic base in good-to-excellent chemical yields without any external stoichiometric oxidants and radical initiators.

引用

页码：5520 / 5523

页数：4

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