Isocyanide Insertion: De Novo Synthesis of Trifluoromethylated Phenanthridine Derivatives

被引：124
作者：
Cheng, Yuanzheng
Jiang, Heng
Zhang, Yan
Yu, Shouyun [1 ]
机构：
[1] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 21期
基金：
中国国家自然科学基金;
关键词：
OXIDATIVE CYCLIZATION; FLUORINE; ARYLATION; PYRIDINE; 6-(TRIFLUOROMETHYL)PHENANTHRIDINES; 2-ISOCYANOBIPHENYLS; HETEROARENES; INHIBITORS; ALKALOIDS; CATALYSIS;
D O I：
10.1021/ol4026827
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl)phenanthridine derivatives using ionic isocyanide insertion from biphenyl isocyanide derivatives and Umemoto's reagent. These reactions were promoted only by inorganic base in good-to-excellent chemical yields without any external stoichiometric oxidants and radical initiators.
引用
收藏
页码：5520 / 5523
页数：4
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