A Thymine Tetrad Assembly Templated from Thymidylic Acid

被引：4

作者：

Bare, Grant A. L. ^{[1
]}

Sherman, John C. ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 16期

基金：

加拿大自然科学与工程研究理事会;

关键词：

G-QUADRUPLEX STRUCTURES; TELOMERIC DNA; RNA TETRAPLEX; G-QUARTET; A-TETRAD; IONS;

D O I：

10.1021/jo401281p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A template tetra-coupled with thymidylic acid through a phosphate linkage was characterized in methanol for emergent properties of nucleobase tetrad formation. Intramolecular hydrogen bonded base pairing in the absence of a cation was indicated for the thymidylic acid species supporting a monomeric template-assembled structure. Thus, an initial report of a stabilized individual thymine tetrad assembly is presented here. Consistent with previous investigations, a deoxyguanylic acid variant templated an analogous methanolic monomeric G-tetrad in comparison to the thymine species.

引用

页码：8198 / 8202

页数：5

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