An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference

被引：7

作者：

Blobel, Gerd A. ^{[1
]}

Bodine, David ^{[2
]}

Brand, Marjorie ^{[3
]}

Crispino, John ^{[4
]}

de Bruijn, Marella F. T. R. ^{[5
,6
]}

Nathan, David ^{[7
,8
]}

Papayannopoulou, Thalia ^{[9
]}

Porcher, Catherine ^{[5
,6
]}

Strouboulis, John ^{[10
]}

Zon, Len ^{[11
]}

Higgs, Douglas R. ^{[5
,6
]}

Stamatoyannopoulos, George ^{[9
]}

Engel, James Douglas ^{[12
]}

机构：

[1] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Div Hematol, Philadelphia, PA 19104 USA

[2] NHGRI, NIH, Bethesda, MD 20892 USA

[3] Ottawa Hosp Res Inst, Sprott Ctr Stem Cell Res, Ottawa, ON, Canada

[4] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Div Hematol Oncol, Chicago, IL 60611 USA

[5] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, MRC Mol Haematol Unit, Oxford OX3 9DU, England

[6] Oxford Univ Hosp, NIHR Oxford Biomed Ctr, BRC Blood Theme, Oxford, England

[7] Harvard Univ, Sch Med, Dana Farber Canc Inst,Dept Pediat,Dept Pediat Onc, Div Hematol & Oncol,Boston Childrens Hosp, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dana Farber Canc Inst,Dept Pediat Oncol,Dept Med, Div Hematol & Oncol,Boston Childrens Hosp, Boston, MA 02115 USA

[9] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

[10] Biomed Sci Res Ctr Alexander Fleming, Div Mol Oncol, Vari, Greece

[11] Boston Childrens Hosp, HHMI, Boston, MA USA

[12] Univ Michigan, Sch Med, Dept Cell & Dev Biol, Ann Arbor, MI USA

来源：

EXPERIMENTAL HEMATOLOGY | 2015年 / 43卷 / 10期

基金：

英国医学研究理事会;

关键词：

CAUSES HEREDITARY PERSISTENCE; FETAL-HEMOGLOBIN; GENE-EXPRESSION; GAMMA-GLOBIN; THERAPY; SINGLE; ADULT; ERYTHROPOIESIS; TRANSCRIPTION; BINDING;

D O I：

10.1016/j.exphem.2015.06.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Every 2 years since 1978, an international group of scientists, physicians, and other researchers meet to discuss the latest developments in the underlying etiology, mechanisms of action, and developmental acquisition of cellular and systemic defects exhibited and elicited by the most common inherited human disorders, the hemoglobinopathies. The 19th Hemoglobin Switching Conference, held in September 2014 at St. John's College in Oxford, once again exceeded all expectations by describing cutting edge research in cellular, molecular, developmental, and genomic advances focused on these diseases. The conference comprised about 60 short talks over 3 days by leading investigators in the field. This meeting report describes the highlights of the conference. Copyright (C) 2015 ISEH - International Society for Experimental Hematology. Published by Elsevier Inc.

引用

页码：821 / 837

页数：17

共 73 条

[11] DEVELOPMENTAL REGULATION OF BETA-GLOBIN GENE SWITCHING
CHOI, ORB
ENGEL, JD
[J]. CELL, 1988, 55 (01) : 17 - 26
[12] Distinct origins of adult and embryonic blood in Xenopus
Ciau-Uitz, A
Walmsley, M
Patient, R
[J]. CELL, 2000, 102 (06) : 787 - 796
[13] Therapeutic genome editing: prospects and challenges
Cox, David Benjamin Turitz
Platt, Randall Jeffrey
Zhang, Feng
[J]. NATURE MEDICINE, 2015, 21 (02) : 121 - 131
[14] PGC-1 Coactivator Activity Is Required for Murine Erythropoiesis
Cui, Shuaiying
Tanabe, Osamu
Lim, Kim-Chew
Xu, H. Eric
Zhou, X. Edward
Lin, Jiandie D.
Shi, Lihong
Schmidt, Lindsay
Campbell, Andrew
Shimizu, Ritsuko
Yamamoto, Masayuki
Engel, James Douglas
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2014, 34 (11) : 1956 - 1965
[15] Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adult Erythroid Cells
Cui, Shuaiying
Kolodziej, Katarzyna E.
Obara, Naoshi
Amaral-Psarris, Alexandra
Demmers, Jeroen
Shi, Lihong
Engel, James Douglas
Grosveld, Frank
Strouboulis, John
Tanabe, Osamu
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2011, 31 (16) : 3298 - 3311
[16] Controlling Long-Range Genomic Interactions at a Native Locus by Targeted Tethering of a Looping Factor
Deng, Wulan
Lee, Jongjoo
Wang, Hongxin
Miller, Jeff
Reik, Andreas
Gregory, Philip D.
Dean, Ann
Blobel, Gerd A.
[J]. CELL, 2012, 149 (06) : 1233 - 1244
[17] Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice
Esteghamat, Fatemehsadat
Gillemans, Nynke
Bilic, Ivan
van den Akker, Emile
Cantu, Ileana
van Gent, Teus
Klingmueller, Ursula
van Lom, Kirsten
von Lindern, Marieke
Grosveld, Frank
van Dijk, Thamar Bryn
Busslinger, Meinrad
Philipsen, Sjaak
[J]. BLOOD, 2013, 121 (13) : 2553 - 2562
[18] INHIBITION OF TRANSLATION IN EUKARYOTIC SYSTEMS BY HARRINGTONINE
FRESNO, M
JIMENEZ, A
VAZQUEZ, D
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 72 (02): : 323 - 330
[19] Discovering Hematopoietic Mechanisms through Genome-wide Analysis of GATA Factor Chromatin Occupancy
Fujiwara, Tohnu
O'Geen, Henriette
Keles, Sunduz
Blahnik, Kimberly
Linnemann, Amelia K.
Kang, Yoon-A.
Choi, Kyunghee
Farnham, Peggy J.
Bresnick, Emery H.
[J]. MOLECULAR CELL, 2009, 36 (04) : 667 - 681
[20] Alternative options for DNA-based experimental therapy of β-thalassemia
Gambari, Roberto
[J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2012, 12 (04) : 443 - 462

← 1 2 3 4 5 6 7 8 →