Cellular reprogramming: a small molecule perspective

被引：29

作者：

Nie, Baoming ^{[1
]}

Wang, Haixia ^{[1
]}

Laurent, Timothy ^{[1
]}

Ding, Sheng ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pharmaceut Chem, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2012年 / 24卷 / 06期

关键词：

PLURIPOTENT STEM-CELLS; HUMAN FIBROBLASTS; MOUSE FIBROBLASTS; DIRECT CONVERSION; SOMATIC-CELLS; FUNCTIONAL-NEURONS; COPY NUMBER; DIFFERENTIATION; GENERATION; CHROMATIN;

D O I：

10.1016/j.ceb.2012.08.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The discovery that somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) by the expression of a few transcription factors has attracted enormous interest in biomedical research and the field of regenerative medicine. iPSCs nearly identically resemble embryonic stem cells (ESCs) and can give rise to all cell types in the body, and thus have opened new opportunities for personalized regenerative medicine and new ways of modeling human diseases. Although some studies have raised concerns about genomic stability and epigenetic memory in the resulting cells, better understanding and control of the reprogramming process should enable enhanced efficiency and higher fidelity in reprogramming. Therefore, small molecules regulating reprogramming mechanisms are valuable tools to probe the process of reprogramming and harness cell fate transitions for various applications.

引用

页码：784 / 792

页数：9

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