A catalytic, mild and efficient protocol for the C-3 aerial hydroxylation of oxindoles

被引：21
|
作者：
Buckley, Benjamin R. [1 ]
Fernandez, Beatriz D-R [1 ]
机构：
[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 08期
关键词：
Oxindole; TBAF; Oxidation; Catalysis; Welwitindoline; INTRAMOLECULAR ALPHA-ARYLATION; HETEROCYCLIC CARBENE LIGANDS; (-)-N-METHYLWELWITINDOLINONE C ISONITRILE; GROWTH-HORMONE SECRETAGOGUES; OXIDIZED WELWITINDOLINONES; MOLECULAR-OXYGEN; AMIDES; ROUTE; ISOTHIOCYANATE; DERIVATIVES;
D O I：
10.1016/j.tetlet.2012.11.083
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A mild, high yielding approach to C-3 hydroxylated oxindoles using catalytic quantities of tetrabutylammonium fluoride and air as the stoicheiometric oxidant is reported over a wide range of substitution patterns. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：843 / 846
页数：4
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