A catalytic, mild and efficient protocol for the C-3 aerial hydroxylation of oxindoles

被引：21

作者：

Buckley, Benjamin R. ^{[1
]}

Fernandez, Beatriz D-R ^{[1
]}

机构：

[1] Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 08期

关键词：

Oxindole; TBAF; Oxidation; Catalysis; Welwitindoline; INTRAMOLECULAR ALPHA-ARYLATION; HETEROCYCLIC CARBENE LIGANDS; (-)-N-METHYLWELWITINDOLINONE C ISONITRILE; GROWTH-HORMONE SECRETAGOGUES; OXIDIZED WELWITINDOLINONES; MOLECULAR-OXYGEN; AMIDES; ROUTE; ISOTHIOCYANATE; DERIVATIVES;

D O I：

10.1016/j.tetlet.2012.11.083

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild, high yielding approach to C-3 hydroxylated oxindoles using catalytic quantities of tetrabutylammonium fluoride and air as the stoicheiometric oxidant is reported over a wide range of substitution patterns. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：843 / 846

页数：4

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