Advancing precision medicine with personalized drug screening

被引：28

作者：

Gorshkov, Kirill ^{[1
]}

Chen, Catherine Z. ^{[1
]}

Marshall, Raisa E. ^{[2
]}

Mihatov, Nino ^{[2
]}

Choi, Yong ^{[2
]}

Dac-Trung Nguyen ^{[1
]}

Southall, Noel ^{[1
]}

Chen, Kevin G. ^{[2
]}

Parke, John K. ^{[2
]}

Zheng, Wei ^{[1
]}

机构：

[1] Natl Ctr Advancing Translat Sci, NIH, Bethesda, MD 20892 USA

[2] NINDS, NIH, Bethesda, MD 20892 USA

来源：

DRUG DISCOVERY TODAY | 2019年 / 24卷 / 01期

基金：

美国国家卫生研究院;

关键词：

CELLS; INFECTIONS; EXPOSOME; TUMORS;

D O I：

10.1016/j.drudis.2018.08.010

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Personalized drug screening (PDS) of approved drug libraries enables rapid development of specific small-molecule therapies for individual patients. With a multidisciplinary team including clinicians, researchers, ethicists, informaticians and regulatory professionals, patient treatment can be optimized with greater efficacy and fewer adverse effects by using PDS as an approach to find remedies. In addition, PDS has the potential to rapidly identify therapeutics for a patient suffering from a disease without an existing therapy. From cancer to bacterial infections, we review specific maladies addressed with PDS campaigns. We predict that PDS combined with personal genomic analyses will contribute to the development of future precision medicine endeavors.

引用

页码：272 / 278

页数：7

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