PfCRT and its role in antimalarial drug resistance

被引：202

作者：

Ecker, Andrea ^{[1
]}

Lehane, Adele M. ^{[1
,2
]}

Clain, Jerome ^{[1
,3
]}

Fidock, David A. ^{[1
,4
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Microbiol & Immunol, New York, NY 10032 USA

[2] Australian Natl Univ, Res Sch Biol, Canberra, ACT 0200, Australia

[3] Paris Descartes Univ, UMR 216, Inst Rech Dev, F-75006 Paris, France

[4] Columbia Univ, Coll Phys & Surg, Dept Med, Div Infect Dis, New York, NY 10032 USA

来源：

TRENDS IN PARASITOLOGY | 2012年 / 28卷 / 11期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

Plasmodium falciparurn; malaria; drug resistance; PfCRT; heme detoxification; haplotypes; selective sweep; transmission; PLASMODIUM-FALCIPARUM CHLOROQUINE; TRANSMEMBRANE PROTEIN PFCRT; IN-VITRO; MALARIA PARASITES; TRANSPORTER PFCRT; DIGESTIVE VACUOLE; ARTEMETHER-LUMEFANTRINE; MOLECULAR EPIDEMIOLOGY; AMODIAQUINE RESISTANCE; PFMDR1; POLYMORPHISMS;

D O I：

10.1016/j.pt.2012.08.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter (PfCRT). These mutations impart upon PfCRT the ability to efflux chloroquine from the intracellular digestive vacuole, the site of drug action. Recent studies reveal that PfCRT variants can also affect parasite fitness, protect immature gametocytes against chloroquine action, and alter P. falciparum susceptibility to current first-line therapies. These results highlight the need to be vigilant in screening for the appearance of novel pfcrt alleles that could contribute to new multidrug resistance phenotypes.

引用

页码：504 / 514

页数：11

共 112 条

[1] Chloroquine Clinical Failures in P. falciparum Malaria Are Associated with Mutant Pfmdr-1, Not Pfcrt in Madagascar [J].

Andriantsoanirina, Valerie ;

Ratsimbasoa, Arsene ;

Bouchier, Christiane ;

Tichit, Magali ;

Jahevitra, Martial ;

Rabearimanana, Stephane ;

Raherinjafy, Rogelin ;

Mercereau-Puijalon, Odile ;

Durand, Remy ;

Menard, Didier .

PLOS ONE, 2010, 5 (10)

[2] Plasmodium falciparum Drug Resistance in Madagascar: Facing the Spread of Unusual pfdhfr and pfmdr-1 Haplotypes and the Decrease of Dihydroartemisinin Susceptibility [J].

Andriantsoanirina, Valerie ;

Ratsimbasoa, Arsene ;

Bouchier, Christiane ;

Jahevitra, Martial ;

Rabearimanana, Stephane ;

Radrianjafy, Rogelin ;

Andrianaranjaka, Voahangy ;

Randriantsoa, Tantely ;

Rason, Marie Ange ;

Tichit, Magali ;

Rabarijaona, Leon Paul ;

Mercereau-Puijalon, Odile ;

Durand, Remy ;

Menard, Didier .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (11) :4588-4597

[3] Molecular epidemiology of malaria in Cameroon.: XIII.: Analysis of pfcrt mutations and in vitro chloroquine resistance [J].

Basco, LK .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 67 (04) :388-391

[4] Molecular epidemiology of malaria in Cameroon.: XII.: In vitro drug assays and molecular surveillance of chloroquine and proguanil resistance [J].

Basco, LK .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2002, 67 (04) :383-387

[5] Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH [J].

Bennett, TN ;

Kosar, AD ;

Ursos, LMB ;

Dzekunov, S ;

Sidhu, ABS ;

Fidock, DA ;

Roepe, PD .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2004, 133 (01) :99-114

[6] Benefits of using multiple first-line therapies against malaria [J].

Boni, Maciej F. ;

Smith, David L. ;

Laxminarayan, Ramanan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (37) :14216-14227

[7] PfCRT and the trans-vacuolar proton electrochemical gradient:: regulating the access of chloroquine to ferriprotoporphyrin IX [J].

Bray, Patrick G. ;

Mungthin, Mathirut ;

Hastings, Ian M. ;

Biagini, Giancarlo A. ;

Saidu, Dauda K. ;

Lakshmanan, Viswanathan ;

Johnson, David J. ;

Hughes, Ruth H. ;

Stocks, Paul A. ;

O'Neill, Paul M. ;

Fidock, David A. ;

Warhurst, David C. ;

Ward, Stephen A. .

MOLECULAR MICROBIOLOGY, 2006, 62 (01) :238-251

[8] Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance [J].

Bray, PG ;

Martin, RE ;

Tilley, L ;

Ward, SA ;

Kirk, K ;

Fidock, DA .

MOLECULAR MICROBIOLOGY, 2005, 56 (02) :323-333

[9] Sequence and gene expression of chloroquine resistance transporter (pfcrt) in the association of in vitro drugs resistance of Plasmodium falciparum [J].

Chaijaroenkul, Wanna ;

Ward, Stephen A. ;

Mungthin, Mathirut ;

Johnson, David ;

Owen, Andrew ;

Bray, Patrick G. ;

Na-Bangchang, Kesara .

MALARIA JOURNAL, 2011, 10

[10] pfcrt allelic types with two novel amino acid mutations in chloroquine-resistant Plasmodium falciparum isolates from the Philippines [J].

Chen, NH ;

Kyle, DE ;

Pasay, C ;

Fowler, EV ;

Baker, J ;

Peters, JM ;

Cheng, Q .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (11) :3500-3505

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