Epigenetic alterations in osteosarcoma: promising targets

被引：27
作者：
Li, Binghao [1 ]
Ye, Zhaoming [2 ]
机构：
[1] Zhejiang Univ, Dept Orthopaed, Sch Med, Affiliated Hosp 2, Hangzhou 310008, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Orthopaed, Ctr Orthopaed Res, Affiliated Hosp 2,Sch Med, Hangzhou 310008, Zhejiang, Peoples R China
来源：
MOLECULAR BIOLOGY REPORTS | 2014年 / 41卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Osteosarcoma; Epigenetics; Combination therapy; Cancer treatment; Tumorigenesis; TUMOR-SUPPRESSOR GENE; HISTONE DEACETYLASE INHIBITORS; ACTIVE DNA DEMETHYLATION; REFRACTORY SOLID TUMORS; MESENCHYMAL STEM-CELLS; CANCER-TESTIS ANTIGEN; STUDY-GROUP PROTOCOLS; HUMAN BREAST-CANCER; PHASE-I; METASTATIC OSTEOSARCOMA;
D O I：
10.1007/s11033-014-3193-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cancer is being reinterpreted due to recent discoveries related to epigenetic regulation during development, and the importance of epigenetic mechanisms in initiation and progression of cancer has been further highlighted by the recent explosion in medical information. Osteosarcoma is highly genetically unstable, and current therapeutic regimens are subject to chemoresistance and tumor relapse. Understanding the epigenetic mechanisms in the pathogenesis of osteosarcoma will provide novel avenues for cancer therapy. In this review, we examine the epigenetic alterations in gene expression in osteosarcoma, and discuss the utilization of epigenetic regulation therapy in treatment against osteosarcoma.
引用
收藏
页码：3303 / 3315
页数：13
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