Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream

被引：1327

作者：

Arkin, MR ^{[1
]}

Wells, JA ^{[1
]}

机构：

[1] Sunesis Pharmaceut, San Francisco, CA 94080 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 04期

关键词：

D O I：

10.1038/nrd1343

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Protein-protein interactions have a key role in most biological processes, and offer attractive opportunities for therapeutic intervention. Developing small molecules that modulate protein-protein interactions is difficult, owing to issues such as the lack of well-defined binding pockets. Nevertheless, there has been important progress in this endeavour in recent years. Here, we use illustrative examples to discuss general strategies for addressing the challenges inherent in the discovery and characterization of small-molecule inhibitors of protein-protein interactions.

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页码：301 / 317

页数：17

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