Nutrimetabonomics: Applications for Nutritional Sciences, with Specific Reference to Gut Microbial Interactions

被引：36

作者：

Claus, Sandrine P. ^{[1
]}

Swann, Jonathan R. ^{[1
]}

机构：

[1] Univ Reading, Dept Food & Nutr Sci, Reading RG6 6AP, Berks, England

来源：

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 4 | 2013年 / 4卷

关键词：

metabonomics; metabolomics; nutrition; gut microbiota; personalized nutrition; DIETARY ISOFLAVONES; CALORIC RESTRICTION; HIGH-RESOLUTION; METABONOMIC TECHNIQUES; METABOLIC PHENOTYPES; INFORMATION RECOVERY; NMR-SPECTROSCOPY; HUMAN HEALTH; TEA; PLASMA;

D O I：

10.1146/annurev-food-030212-182612

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Understanding the role of the diet in determining human health and disease is one major objective of modern nutrition. Mammalian biocomplexity necessitates the incorporation of systems biology technologies into contemporary nutritional research. Metabonomics is a powerful approach that simultaneously measures the low-molecular-weight compounds in a biological sample, enabling the metabolic status of a biological system to be characterized. Such biochemical profiles contain latent information relating to inherent parameters, such as the genotype, and environmental factors, including the diet and gut microbiota. Nutritional metabonomics, or nutrimetabonomics, is being increasingly applied to study molecular interactions between the diet and the global metabolic system. This review discusses three primary areas in which nutrimetabonomics has enjoyed successful application in nutritional research: the illumination of molecular relationships between nutrition and biochemical processes; elucidation of biomarker signatures of food components for use in dietary surveillance; and the study of complex trans-genomic interactions between the mammalian host and its resident gut microbiome. Finally, this review illustrates the potential for nutrimetabonomics in nutritional science as an indispensable tool to achieve personalized nutrition.

引用

页码：381 / 399

页数：19

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