Antibacterial and anticancer activity of loaded quinazolinone polypyrrole/chitosan silver chloride nanocomposite

被引：12

作者：

Salahuddin, Nehal ^{[1
]}

Elbarbary, Ahmed A. ^{[1
]}

Alkabes, Hend A. ^{[1
]}

机构：

[1] Tanta Univ, Dept Chem, Fac Sci, Tanta 31527, Egypt

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2017年 / 66卷 / 06期

关键词：

Conducting polymers; polypyrrole chitosan; polypyrrole chitosan silver chloride; quinazolinone and anticancer activity; ELECTROCHEMICALLY CONTROLLED-RELEASE; ANTIMICROBIAL ACTIVITY; FACILE SYNTHESIS; NANOPARTICLES; CHITOSAN; AGCL; COMPOSITE; POLYANILINE; DERIVATIVES; CELLS;

D O I：

10.1080/00914037.2016.1201831

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Polypyrrole/chitosan-silver chloride core shell nanocomposite (AgCl@PPC) was prepared by in situ oxidative polymerization of pyrrole (Py) using ferric chloride in the presence of chitosan (CS) and silver nitrate to develop a carrier and controlled release system for 3-amino-2-phenyl-4(3H)-quinazolinone (I). For sake of comparison, polypyrrole chitosan core shell nanoparticles (PPC) were prepared and loaded by (I). Fourier transform infrared spectroscopy, X-ray diffraction and thermal gravimetric analysis confirm that I was loaded into PPC and AgCl@PPC core shell nanocomposites respectively, through physical interaction. Results revealed that loaded AgCl@PPC and PPC exhibited excellent antibacterial and anticancer efficacy against Ehrlich ascites carcinoma cells.

引用

页码：307 / 316

页数：10

共 77 条

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