Dengue fever and human T-cell lymphotropic virus type 1 infection

被引：1

作者：

Longo, Cecilia Lameirinhas ^{[1
]}

Brasil, Patricia ^{[1
]}

Espindola, Otavio de Melo ^{[2
]}

Celestino Bezerra Leite, Ana Claudia ^{[3
]}

Ribeiro Nogueira, Rita Maria ^{[4
]}

Lupi, Otilia ^{[1
]}

Neves, Elizabeth de Souza ^{[1
]}

机构：

[1] Fiocruz MS, Inst Pesquisa Clin Evandro Chagas, Lab Pesquisa Clin Doencas Infecciosas, BR-21045900 Rio De Janeiro, Brazil

[2] Fiocruz MS, Inst Pesquisa Clin Evandro Chagas, Lab Pesquisa Patogenia Viral, BR-21045900 Rio De Janeiro, Brazil

[3] Fiocruz MS, Inst Pesquisa Clin Evandro Chagas, Lab Pesquisa Clin Neuroinfeccao, BR-21045900 Rio De Janeiro, Brazil

[4] Fiocruz MS, Inst Oswaldo Cruz, Lab Flavivirus, BR-21045900 Rio De Janeiro, Brazil

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2013年 / 17卷 / 07期

关键词：

HTLV-1; Dengue fever; Co-infection; MYELOPATHY/TROPICAL SPASTIC PARAPARESIS; ASYMPTOMATIC CARRIERS; HTLV-1; INFECTION; PROVIRAL LOAD; TNF-ALPHA; CYTOKINES;

D O I：

10.1016/j.ijid.2013.01.014

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Globalization has increased both the number of emergent diseases and the diversity of co-infections, which could in turn mutually influence the pathogenesis of well-known infectious diseases. Here, we report the first series of chronic human T-cell lymphotropic virus type 1 (HTLV-1) patients co-infected with the dengue fever virus. As both of these diseases are immuno-mediated, we anticipated interference in the development of both diseases, with atypical clinical and laboratory parameter results. All the patients had classic dengue fever, and the main outstanding abnormality was leukopenia associated with lymphopenia. Although a mutual influence was expected, dengue fever did not affect the clinical course of HTLV-1 infection, and HTLV-1 proviral loads revealed unpredictable patterns of change. (C) 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

收藏

页码：E562 / E564

页数：3

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