A comparative study of cytotoxic, membrane and DNA damaging effects of Origanum majorana's essential oil and its oxygenated monoterpene component linalool on parental and epirubicin-resistant H1299 cells

被引:16
作者
Erdogan, Ayse [1 ]
Ozkan, Aysun [1 ]
机构
[1] Akdeniz Univ, Fac Sci, Dept Biol, TR-07058 Antalya, Turkey
关键词
Origanum majorana; essential oil; linalool; DNA damage; membrane damage; parental and epirubicin-resistant H1299 cell line; MITOCHONDRIAL-MEMBRANE; ANTICANCER ACTIVITY; LIPID-PEROXIDATION; AQUEOUS EXTRACTS; REACTIVE OXYGEN; ANTIOXIDANT; MECHANISMS; INHIBITION; CARVACROL; MARJORAM;
D O I
10.2478/s11756-013-0196-0
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
In this study, cytotoxic, membrane and DNA damaging effects of the essential oil from Origanum majorana and its oxygenated monoterpene component linalool were tested on parental and epirubicin-resistant (drug-resistant) human lung cancer cell lines (H1299). Essential oil's and linalool's cytotoxicities were examined and parental cells were found more sensitive to the essential oil's and linalool's cytotoxicities than drug-resistant cells. O. majorana essential oil had more effective membrane damaging effect than linalool on parental cells, while in drug-resistant H1299 cells, linalool had more effective membrane damaging effect than the essential oil. O. majorana essential oil possessed more effective DNA damaging effect than linalool on both parental and drug-resistant cells. The conclusions from this study suggest that O. majorana essential oil and linalool exhibit cytotoxic, membrane and DNA damaging effects. They thus need further investigation as potential therapeutic agents for human lung cancer.
引用
收藏
页码:754 / 761
页数:8
相关论文
共 54 条
[1]   The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line [J].
Abdel-Massih, Roula M. ;
Fares, Rida ;
Bazzi, Samer ;
El-Chami, Nisrine ;
Baydoun, Elias .
LEUKEMIA RESEARCH, 2010, 34 (08) :1052-1056
[2]   Protective Effect of Origanum majorana L. 'Marjoram' on Various Models of Gastric Mucosal Injury in Rats [J].
Al-Howiriny, Tawfeq ;
Alsheikh, Abdulmalik ;
Alqasoumi, Saleh ;
Al-Yahya, Mohammed ;
ElTahir, Kamal ;
Rafatullah, Syed .
AMERICAN JOURNAL OF CHINESE MEDICINE, 2009, 37 (03) :531-545
[3]   Mitochondrial membrane permeabilization: the sine qua non for cell death [J].
Armstrong, JS .
BIOESSAYS, 2006, 28 (03) :253-260
[4]   Biological effects of essential oils - A review [J].
Bakkali, F. ;
Averbeck, S. ;
Averbeck, D. ;
Waomar, M. .
FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (02) :446-475
[5]   GERANIOL INTERFERES WITH MEMBRANE FUNCTIONS IN STRAINS OF CANDIDA AND SACCHAROMYCES [J].
BARD, M ;
ALBRECHT, MR ;
GUPTA, N ;
GUYNN, CJ ;
STILLWELL, W .
LIPIDS, 1988, 23 (06) :534-538
[6]   The free radical theory of aging matures [J].
Beckman, KB ;
Ames, BN .
PHYSIOLOGICAL REVIEWS, 1998, 78 (02) :547-581
[7]   A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients [J].
Bickers, D ;
Calow, P ;
Greim, H ;
Hanifin, JM ;
Rogers, AE ;
Saurat, JH ;
Sipes, IG ;
Smith, RL ;
Tagami, H .
FOOD AND CHEMICAL TOXICOLOGY, 2003, 41 (07) :919-942
[8]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[9]   Sensitization of Staphylococcus aureus and Escherichi coli to antibiotics by the sesquiterpenoid nerolidol, farnesol, bisabolol, and apritone [J].
Brehm-Stecher, BF ;
Johnson, EA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (10) :3357-3360
[10]   THE PECKING ORDER OF FREE-RADICALS AND ANTIOXIDANTS - LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, AND ASCORBATE [J].
BUETTNER, GR .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (02) :535-543