Structures and antipathogenic fungi activities of flavonoids from pathogen-infected Astragalus adsurgens

被引:14
作者
Li, Ya [1 ]
Wei, Wenjun [1 ]
Zhang, Jiwen [2 ]
Li, Guangda [1 ]
Gao, Kun [1 ]
机构
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou, Gansu, Peoples R China
[2] Northwest A&F Univ, Key Lab Bot Pesticide R&D Shaanxi Prov, Yangling, Shaanxi, Peoples R China
基金
中国国家自然科学基金;
关键词
Astragalus adsurgens; flavonoids; pathogenic infection; antipathogenic fungi activity; RESISTANCE; DIVERSITY;
D O I
10.1080/14786419.2017.1413560
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Healthy Astragalus adsurgens is a highly palatable forage widely cultivated in arid areas of north China, while pathogen- (Embellisia asttrgali) infected A. adsurgens is poisonous forage and often causes disastrous livestock losses. A phytochemical investigation was carried out on the E. asttrgali-infected A. adsurgens; as a result, a new compound, (2R, 3S)-7,4 '-dimethoxy-2 '-hydroxyflavanol (1), together with nine known flavonoids was obtained. It was found that the content of most of these compounds in E. asttrgali-infected A. adsurgens was higher than that in healthy A. adsurgens. Moreover, compounds 2 and 3 exhibited weak inhibitory activity against Fusarium graminearum and E. asttrgali with EC50 over 100 mu g/mL, and showed moderate inhibitory activity against Bipolaris sorokinianum with EC50 of 39.1 and 95.0 mu g/mL. Compounds 1-4 exhibited a high degree of inhibitory activity against Curvularia lunata, with 21.73, 43.93, 45.02 and 44.51% inhibition ratio at concentration of 50 mu g/mL. [GRAPHICS] .
引用
收藏
页码:822 / 826
页数:5
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