A greater birthweight increases the risk of acute leukemias in Mexican children-experience from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia (MIGICCL)

被引：10

作者：

Jimenez-Hernandez, Elva ^{[1
,2
]}

Fajardo-Gutierrez, Arturo ^{[3
]}

Carlos Nunez-Enriquez, Juan ^{[3
]}

Alfonso Martin-Trejo, Jorge ^{[4
]}

Eugenia Espinoza-Hernandez, Laura ^{[2
]}

Flores-Lujano, Janet ^{[3
]}

Arellano-Galindo, Jose ^{[5
]}

Medina-Sanson, Aurora ^{[5
]}

Paredes-Aguilera, Rogelio ^{[6
]}

Elizabeth Merino-Pasaye, Laura ^{[7
]}

Margarita Velazquez-Avina, Martha ^{[8
]}

Refugio Torres-Nava, Jose ^{[9
]}

Martha Espinosa-Elizondo, Rosa ^{[10
]}

Amador-Sanchez, Raquel ^{[11
]}

Jose Dosta-Herrera, Juan ^{[12
]}

Anastacio Mondragon-Garcia, Javier ^{[13
]}

Valdes-Guzman, Heriberto ^{[14
]}

Mejia-Perez, Laura ^{[15
]}

Espinoza-Anrubio, Gilberto ^{[16
]}

Minerva Paz-Bribiesca, Maria ^{[17
]}

Salcedo-Lozada, Perla ^{[18
]}

Angel Landa-Garcia, Rodolfo ^{[19
]}

Ramirez-Colorado, Rosario ^{[20
]}

Hernandez-Mora, Luis ^{[21
]}

Luisa Perez-Saldivar, Maria ^{[3
]}

Santamaria-Ascencio, Marlene ^{[22
]}

Lopez-Loyola, Anselmo ^{[23
]}

Hermilo Godoy-Esquivel, Arturo ^{[24
]}

Ramiro Garcia-Lopez, Luis ^{[25
]}

Ireri Anguiano-Avalos, Alison ^{[26
]}

Mora-Rico, Karina ^{[27
]}

Castaneda-Echevarria, Alejandro ^{[28
]}

Rodriguez-Jimenez, Roberto ^{[29
]}

Alberto Cibrian-Cruz, Jose ^{[30
]}

Anastacia Solis-Labastida, Karina ^{[4
]}

Cardenas-Cardos, Rocio ^{[31
]}

Martinez-Avalos, Armando ^{[31
]}

Victoria Flores-Villegas, Luz ^{[7
]}

Gabriel Penaloza-Gonzalez, Jose ^{[8
]}

Itamar Gonzalez-Avila, Ana ^{[11
]}

Beatriz Altamirano-Garcia, Martha ^{[16
]}

Lopez-Santiago, Norma ^{[6
]}

Sanchez-Ruiz, Martin ^{[18
]}

Rivera-Luna, Roberto ^{[31
]}

Rodolfo Rodriguez-Villalobos, Luis ^{[25
]}

Hernandez-Perez, Francisco ^{[26
]}

Angel Olvera-Duran, Jaime ^{[27
]}

Rey Garcia-Cortes, Luis ^{[32
]}

Mata-Rocha, Minerva ^{[33
]}

Alejandro Sepulveda-Robles, Omar ^{[33
]}

机构：

[1] IMSS, Hlth Res Coordinat, Mexico City, DF, Mexico

[2] IMSS, CMN La Raza, Hosp Gen Gaudencio Gonzalez Garza, Pediat Hematol Serv, Mexico City, DF, Mexico

[3] IMSS, UMAE Hosp Pediat CMN Siglo 21, Med Res Unit Clin Epidemiol, Mexico City, DF, Mexico

[4] IMSS, UMAE Hosp Pediatria CMN Siglo 21, Hematol Serv, Mexico City, DF, Mexico

[5] Childrens Hosp Mexico, Federico Gomez, SS, Mexico City, DF, Mexico

[6] INP, Hematol Serv, SS, Mexico City, DF, Mexico

[7] ISSSTE, CMN Noviembre 20, Pediat Hematol Serv, Mexico City, DF, Mexico

[8] Hosp Juarez Mexico, SS, Oncopediat Serv, Mexico City, DF, Mexico

[9] Secretaria Salud Ciudad Mexico SSCDMX, Hosp Pediat Moctezuma, Oncol Serv, Mexico City, DF, Mexico

[10] Hosp Gen Mexico City, SSa, Pediat Hematol Serv, Mexico City, DF, Mexico

[11] Hosp Gen Reg HGR 1 Dr Carlos Mac Gregor Sanchez N, Pediat Hematol Serv, Mexico City, DF, Mexico

[12] IMSS, Hosp Gen Gaudencio Gonzalez Garza CMN Raza, Pediat Surg Serv, Mexico City, DF, Mexico

[13] HGR 1 Dr Carlos Mac Gregor Sanchez Navarro IMSS, Pediat Surg Serv, Mexico City, DF, Mexico

[14] Pediat Hosp Iztacalco, SSCDMX, Mexico City, DF, Mexico

[15] Pediat Hosp Iztapalapa, SSCDMX, Mexico City, DF, Mexico

[16] Hosp Gen Zona HGZ 8 Dr Gilberto Flores Izquierdo, Serv Pediat, Mexico City, DF, Mexico

[17] Hosp Juarez Ctr, Pediat Serv, SS, Mexico City, DF, Mexico

[18] ISEM, Gen Hosp Ecatepec Las Amer, Mexico City, DF, Mexico

[19] Gen Hosp Dr Manuel Gea Gonzalez SS, Mexico City, DF, Mexico

[20] Pediat Hosp La Villa, SSCDMX, Mexico City, DF, Mexico

[21] Pediat Hosp San Juan Aragon, SSCDMX, Mexico City, DF, Mexico

[22] IMSS, HGR Lic Vicente Santos Guajardo 72, Pediat Serv, Mexico City, DF, Mexico

[23] IMSS, HGZ 32, Pediat Surg Serv, Mexico City, DF, Mexico

[24] Hosp Pediat Moctezuma, Pediat Surg Serv, SSCDMX, Mexico City, DF, Mexico

[25] Hosp Pediat Tacubaya, Pedia Serv, SSCDMX, Mexico City, DF, Mexico

[26] IMSS, HGZ 47, Pediat ER, Mexico City, DF, Mexico

[27] Hosp Reg 1 Octubre, ISSSTE, Pediat Surg Serv, Mexico City, DF, Mexico

[28] IMSS, HGR 25, Mexico City, DF, Mexico

[29] Hosp Gen Zona Con Med Familiar HGZMF 29 IMSS, Pediat Serv, Mexico City, DF, Mexico

[30] IMSS, HGZ 27, Pediat Surg Serv, Mexico City, DF, Mexico

[31] SSa, INP, Oncol Serv, Mexico City, DF, Mexico

[32] IMSS, Delegac Reg Estado Mexico Oriente, Mexico City, DF, Mexico

[33] IMSS, CMN Siglo 21, Hosp Pediatria, Mol Biol Lab,UMAE, Mexico City, DF, Mexico

[34] IMSS, Hosp Infectol Dr Daniel Mendez Hernandez CMN La R, Unidad Invest Med Inmunol & Infectol, Lab Coordinat Epidemiol Surveillance & Support Co, Mexico City, DF, Mexico

[35] IMSS, Hosp Infectol Dr Daniel Mendez Hernandez CMN La R, Med Res Unit Immunol & Infectol, Mexico City, DF, Mexico

[36] Inst Nacl Med Genom, Canc Genom Lab, Mexico City, DF, Mexico

[37] IMSS, CMN Siglo 21, Hosp Pediat, Med Res Unit Human Genet,UMAE, Mexico City, DF, Mexico

来源：

CANCER MEDICINE | 2018年 / 7卷 / 04期

关键词：

Birthweight; children; epidemiology; leukemia; risk factors; ACUTE LYMPHOBLASTIC-LEUKEMIA; GROWTH-FACTOR-I; FETAL-GROWTH; METAANALYSIS; SMOKING;

D O I：

10.1002/cam4.1414

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In Mexico, due to the high rates of diabetes, overweight, and obesity, there has also been noted an increased newborn weight, which may be contributing to the elevated incidence rate of childhood acute leukemia (AL). We conducted a case-control study in public hospitals of Mexico City aimed to know whether a greater weight at birth is associated with a higher risk of developing leukemia. We included incident cases with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) diagnosed between 2010 and 2015. Controls were frequency-matched to the cases by age, sex, and health institution. Logistic regression analysis was performed adjusting risks by child's sex, overcrowding index, birth order, and mother's age at the time of pregnancy. Adjusted odds ratios (aORs) and 95% confidence intervals were calculated. A total of 1455 cases and 1455 controls were included. An evident association between ALL and child's birthweight >= 2500g was found (aOR 2.06; 95% CI: 1.59, 2.66) and also, in those with birthweight >= 3500g (aOR 1.19; 95% CI: 1.00, 1.41). In AML patients with birthweight >= 2500g and >= 3500g, an aOR of 1.77 (95% CI: 1.07, 2.94) and 1.42 (95% CI: 1.03-1.95) was observed, respectively. No association was noticed with either type of AL and a birthweight >= 4000g. To sum up, we found a moderate association between not having a low birthweight and an increased risk of acute leukemias. Birthweight >= 3500g was also a risk factor for both types of leukemia. This suggests that a greater birthweight may increase the risk of acute leukemias in Mexican children.

引用

页码：1528 / 1536

页数：9

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