Studies on conducting polymer intercalated layered double hydroxide nanocomposites: Antituberculosis drug delivery agents

被引：12
|
作者：
Riaz, Ufana [1 ]
Singh, Neetika [1 ]
Verma, Anurakshee [1 ]
Aazam, Elham S. [2 ]
机构：
[1] Jamia Millia Islamia, Dept Chem, Mat Res Lab, New Delhi 110025, India
[2] King Abdulaziz Univ, Fac Sci, Chem Dept, Jeddah, Saudi Arabia
来源：
POLYMER ENGINEERING AND SCIENCE | 2020年 / 60卷 / 10期
关键词：
clay; composites; drug delivery systems; modification; X-ray; IN-VITRO; GREEN SYNTHESIS; RELEASE; RIFAMPICIN;
D O I：
10.1002/pen.25530
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
The synthesis of layered double hydroxide (LDH) was carried out using different ratios of Mg:Al. The intercalation of polypyrrole (Ppy) within interlayer space of LDH was carried out via ultrasonication using different loadings of the conducting polymer. Fourier transform infrared (FTIR) spectra and XRD analysis showed successful intercalation of Ppy in LDH while UV-visible spectra confirmed polaronic state of the conducting polymer within the LDH. Scanning electron microscopy and transmission electron microscopy studies showed successful incorporation of Ppy and loading of the drug was also established. The concentration of Rifampicin, an antituberculosis drug in LDH/Ppy, was confirmed by Langmuir adsorption isotherm. The in vitro release characteristics showed sustained release behaviour at pH 7.4 for a period of 180 hours. The nanocomposites exhibited immense potential for their application as Rifampicin drug carriers.
引用
收藏
页码：2628 / 2639
页数：12
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