Drug Hepatotoxicity Environmental Factors

被引：27
作者：
Stine, Jonathan G. [1 ]
Chalasani, Naga P. [2 ]
机构：
[1] Univ Virginia, Dept Med, Div Gastroenterol & Hepatol, 1215 Lee St,POB 800708,MSB 2145, Charlottesville, VA 22908 USA
[2] Indiana Univ Sch Med, Dept Med, Div Gastroenterol & Hepatol, 702 Rotary Bldg,Suite 225, Indianapolis, IN 46202 USA
来源：
CLINICS IN LIVER DISEASE | 2017年 / 21卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Drug-induced liver injury; Liver toxicity; Cirrhosis; Acute liver failure; Alcohol; Smoking; INDUCED LIVER-INJURY; ACETAMINOPHEN-INDUCED HEPATOTOXICITY; NECROSIS-FACTOR-ALPHA; TERM-FOLLOW-UP; ALCOHOL-CONSUMPTION; PARACETAMOL HEPATOTOXICITY; THERAPEUTIC MISADVENTURE; ANTIRETROVIRAL THERAPY; CARBON-TETRACHLORIDE; CIRCADIAN VARIATION;
D O I：
10.1016/j.cld.2016.08.008
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Drug-induced liver injury presents as various forms of acute and chronic liver disease. There is wide geographic variation in the most commonly implicated agents. Smoking can induce cytochrome P450 enzymes but this does not necessarily translate into clinically relevant drug-induced liver injury. Excessive alcohol consumption is a clear risk factor for intrinsic hepatotoxicity from acetaminophen and may predispose to injury from antituberculosis medications. Understanding of the role of infection, proinflammatory states, disorders of coagulation, and the hepatic clock in predisposing patients to drug-induced liver injury is evolving. More study focusing specifically on environmental risk factors predisposing patients to drug-induced liver injury is needed.
引用
收藏
页码：103 / +
页数：12
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