Light-Triggered Sequence-Specific Cargo Release from DNA Block Copolymer-Lipid Vesicles

被引：74

作者：

Rodriguez-Pulido, Alberto ^{[1
]}

Kondrachuk, Alina I. ^{[1
]}

Prusty, Deepak K. ^{[1
]}

Gao, Jia ^{[2
]}

Loi, Maria A. ^{[2
]}

Herrmann, Andreas ^{[1
]}

机构：

[1] Univ Groningen, Zernike Inst Adv Mat, Dept Polymer Chem, NL-9747 AG Groningen, Netherlands

[2] Univ Groningen, Dept Photophys & Optoelect, NL-9747 AG Groningen, Netherlands

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 03期

关键词：

Block copolymers; DNA; liposomes; nanocontainers; singlet oxygen; LIPOSOMAL DRUG-DELIVERY; OXIDATIVE STRESS; SINGLET OXYGEN; NANOCONTAINERS; NANOPARTICLES; CHOLESTEROL; MEMBRANES; FUSION; PERMEABILIZATION; PHOTOSENSITIZER;

D O I：

10.1002/anie.201206783

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Vesicle buster: Versatile functionalized nanocontainers, based on the stable incorporation of 22 mer DNA-b-PPO block copolymers (DBCs) into lipid vesicles, are presented (see picture). The study shows effective and sequence-specific cargo release from the DBC-lipid vesicles. Hybridization of these vesicles with an oligonucleotide photosensitizer allows for singlet oxygen generation upon irradiation, which induces cargo release. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1008 / 1012

页数：5

共 61 条

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