The discovAIR project: a roadmap towards the Human Lung Cell Atlas

被引：17

作者：

Luecken, Malte D. ^{[1
]}

Zaragosi, Laure-Emmanuelle ^{[2
,3
]}

Madissoon, Elo ^{[4
,5
]}

Sikkema, Lisa ^{[1
]}

Firsova, Alexandra B. ^{[6
]}

De Domenico, Elena ^{[7
]}

Kuemmerle, Louis ^{[1
]}

Saglam, Adem ^{[7
]}

Berg, Marijn ^{[8
,9
]}

Gay, Aurore C. A. ^{[8
,9
]}

Schniering, Janine ^{[10
]}

Mayr, Christoph H. ^{[10
]}

Abalo, Xesus M. ^{[11
]}

Larsson, Ludvig ^{[11
]}

Sountoulidis, Alexandros ^{[6
]}

Teichmann, Sarah A. ^{[4
,12
]}

Van Eunen, Karen ^{[13
,14
]}

Koppelman, Gerard H. ^{[9
,13
]}

Saeb-Parsy, Kourosh ^{[15
,16
]}

Leroy, Sylvie ^{[17
,18
]}

Powell, Pippa ^{[19
]}

Sarkans, Ugis ^{[5
]}

Timens, Wim ^{[8
,9
]}

Lundeberg, Joakim ^{[20
]}

van den Berge, Maarten ^{[9
,21
]}

Nilsson, Mats ^{[11
]}

Horvath, Peter ^{[22
]}

Denning, Jessica ^{[19
]}

Papatheodorou, Irene ^{[5
]}

Schultze, Joachim L. ^{[7
,23
,24
,25
]}

Schiller, Herbert B. ^{[10
]}

Barbry, Pascal ^{[2
,3
]}

Petoukhov, Ilya ^{[26
]}

Misharin, Alexander V. ^{[27
]}

Adcock, Ian M. ^{[28
]}

von Papen, Michael ^{[29
]}

Theis, Fabian J. ^{[1
]}

Samakovlis, Christos ^{[6
]}

Meyer, Kerstin B. ^{[4
]}

Nawijn, Martijn C. ^{[8
,9
]}

机构：

[1] Helmholtz Zentrum Munchen, Inst Computat Biol, German Res Ctr Environm Hlth, Neuherberg, Germany

[2] Univ Cote dAzur, Sophia Antipolis, France

[3] CNRS, Inst Pharmacol Mol & Cellulaire, Sophia Antipolis, France

[4] Wellcome Sanger Inst, Hinxton, England

[5] European Bioinformat Inst, European Mol Biol Lab, Hinxton, England

[6] Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Sci Life Lab, Stockholm, Sweden

[7] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, Syst Med, Bonn, Germany

[8] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

[9] Univ Med Ctr Groningen, GRIAC Res Inst, Groningen, Netherlands

[10] Helmholtz Zentrum Munchen, Inst Lung Biol & Dis, Comprehens Pneumol Ctr, German Ctr Lung Res DZL, Munich, Germany

[11] Stockholm Univ, Dept Biochem & Biophys, Sci Life Lab, Solna, Sweden

[12] Univ Cambridge, Cavendish Lab, Condensed Matter Theory Grp, Cambridge, England

[13] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands

[14] Univ Med Ctr Groningen, UMCG Res BV, Groningen, Netherlands

[15] Univ Cambridge, Dept Surg, Cambridge, England

[16] Cambridge NIHR Biomed Res Ctr, Cambridge, England

[17] Univ Cote dAzur, Dept Pneumol, Nice, France

[18] CHU Nice, FHU OncoAge, Nice, France

[19] European Lung Fdn, Sheffield, S Yorkshire, England

[20] KTH Royal Inst Technol, Dept Gene Technol, Sci Life Lab, Solna, Sweden

[21] Univ Groningen, Univ Med Ctr Groningen, Dept Pulmonol, Groningen, Netherlands

[22] Biol Res Ctr, Synthet & Syst Biol Unit, Szeged, Hungary

[23] Deutsch Zentrum Neurodegenerat Erkrankungen DZNE, PRECISE Platform Single Cell Genom & Epigenom, Med Syst, Bonn, Germany

[24] Univ Bonn, Bonn, Germany

[25] Univ Bonn, Genom & Immunoregulat Life & Med Sci LIMES Inst, Bonn, Germany

[26] A Beta World, Amsterdam, Netherlands

[27] Northwestern Univ, Feinberg Sch Med, Div Pulm & Crit Care Med, Chicago, IL USA

[28] Imperial Coll London, Natl Heart & Lung Inst, Airway Dis Sect, Fac Med, London, England

[29] Comma Soft AG, Bonn, Germany

来源：

EUROPEAN RESPIRATORY JOURNAL | 2022年 / 60卷 / 02期

关键词：

D O I：

10.1183/13993003.02057-2021

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The Lung Biological Network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and cell-cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework programme. discovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Human Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Human Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.

引用

页数：11

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