Mortality and Causes of Death in Psoriatic Arthritis

被引:28
作者
Arumugam, Ramani [1 ]
McHugh, Neil J. [1 ]
机构
[1] Royal Natl Hosp Rheumat Dis, Dept Rheumatol, Bath BA1 1RL, Avon, England
关键词
PSORIATIC ARTHROPATHY; MORTALITY; CAUSES OF DEATH; EPIDEMIOLOGY; THERAPY; RISK; ATHEROSCLEROSIS;
D O I
10.3899/jrheum.120239
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To evaluate the mortality associated with psoriatic arthritis (PsA) and causes of death. Methods. Data were evaluated from several published studies identified by a literature search. A standardized mortality ratio was documented when available, as were causes of death derived from clinical databases, death certificates, and mortality databases. In some studies, mortality data was stratified by sex, age, and calendar year with time trend analysis. Results. There were variable reports of increased mortality in PsA that may be explained by factors such as pattern of referral, the severity of arthritis and/or skin psoriasis, and treatment exposure. There appears to be a greater incidence of cardiovascular death in psoriatic disease, although further studies are needed to separate the effect of skin psoriasis from arthritis. Conclusion. PsA is not a mild disease and mortality may be increased in more severe disease. Although cardiovascular risk is more substantiated in severe psoriasis than in arthritis, it would be remiss not to evaluate the cardiovascular risk profile in all patients with psoriatic disease. It is important to treat patients with PsA early and aggressively to prevent disease severity that may influence longevity. (J Rheumatol 2012;39 Suppl 89:32-35; doi:10.3899/jrheum.120239)
引用
收藏
页码:32 / 35
页数:4
相关论文
共 19 条
[1]  
Alamanos Y, 2003, J RHEUMATOL, V30, P2641
[2]   Improved survival in psoriatic arthritis with calendar time [J].
Ali, Yaser ;
Tom, Brian D. M. ;
Schentag, Catherine T. ;
Farewell, Vernon T. ;
Gladman, Dafna D. .
ARTHRITIS AND RHEUMATISM, 2007, 56 (08) :2708-2714
[3]  
ALONSO JCT, 1991, BRIT J RHEUMATOL, V30, P245
[4]   Tumor Necrosis Factor-α Antagonists Improve Aortic Stiffness in Patients With Inflammatory Arthropathies A Controlled Study [J].
Angel, Kristin ;
Provan, Sella Aarrestad ;
Gulseth, Hanne Lovdahl ;
Mowinckel, Petter ;
Kvien, Tore Kristian ;
Atar, Dan .
HYPERTENSION, 2010, 55 (02) :333-338
[5]   Mortality in Psoriatic Arthritis - A Single-center Study from the UK [J].
Buckley, Caitriona ;
Cavill, Charlotte ;
Taylor, Gordon ;
Kay, Hazel ;
Waldron, Nicola ;
Korendowych, Eleanor ;
McHugh, Neil .
JOURNAL OF RHEUMATOLOGY, 2010, 37 (10) :2141-2144
[6]   Reduction in the incidence of myocardial infarction in patients with rheumatoid arthritis who respond to anti-tumor necrosis factor α therapy -: Results from the British Society for Rheumatology Biologics Register [J].
Dixon, W. G. ;
Watson, K. D. ;
Lunt, M. ;
Silman, A. J. ;
Hyrich, K. L. ;
Symmons, D. P. M. .
ARTHRITIS AND RHEUMATISM, 2007, 56 (09) :2905-2912
[7]  
Eder L, 2008, J RHEUMATOL, V35, P877
[8]   The risk of mortality in patients with psoriasis - Results from a population-based study [J].
Gelfand, Joel M. ;
Troxel, Andrea B. ;
Lewis, James D. ;
Kurd, Shanu Kohli ;
Shin, Daniel B. ;
Wang, Xingmei ;
Margolis, David J. ;
Strom, Brian L. .
ARCHIVES OF DERMATOLOGY, 2007, 143 (12) :1493-1499
[9]   NATURAL-HISTORY OF PSORIATIC-ARTHRITIS [J].
GLADMAN, DD .
BAILLIERES CLINICAL RHEUMATOLOGY, 1994, 8 (02) :379-394
[10]  
GLADMAN DD, 1987, Q J MED, V62, P127