1,2,4-triazoles. Improved synthesis of 5-substituted 4-amino-3-mercato-(4H)-1,2,4-triazoles and a facile route to 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

被引：51

作者：

Invidiata, FP ^{[1
]}

Furno, G ^{[1
]}

Lampronti, I ^{[1
]}

Simoni, D ^{[1
]}

机构：

[1] UNIV FERRARA,DIPARTIMENTO SCI FARMACEUT,I-44100 FERRARA,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 04期

关键词：

D O I：

10.1002/jhet.5570340427

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reaction of thiocarbohydrazide with carboxylic acids at the melting temperature allows an improved preparation of the 5-substituted 4-amino-3-mercapto-1,2,4-triazole heterocycles. The crude 4-amino-5-mercapto-1,2,4-triazoles react easily with carboxylic acids or carboxylic acid chlorides to afford the 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole ring system.

引用

页码：1255 / 1258

页数：4