Rational synthesis of magnetic Fe3O4@MOF nanoparticles for sustained drug delivery

被引：35
作者：
Ke, Xiang [1 ,2 ]
Song, Xiaoqiong [3 ]
Qin, Nianqiao [4 ]
Cai, Yingrun [4 ]
Ke, Fei [4 ]
机构：
[1] Univ Sci & Technol China, Dept Pharm, Affiliated Hosp 1, Hefei 230031, Peoples R China
[2] Anhui Prov Canc Hosp, Hefei 230031, Peoples R China
[3] Hefei Ctr Dis Control & Prevent, Hefei 230022, Anhui, Peoples R China
[4] Anhui Agr Univ, Dept Appl Chem, Hefei 230036, Anhui, Peoples R China
来源：
JOURNAL OF POROUS MATERIALS | 2019年 / 26卷 / 03期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Metal-organic frameworks; Porous materials; Magnetic nanoparticles; Core-shell; Drug delivery; METAL-ORGANIC FRAMEWORKS; CD-MOF; MICROSPHERES; RELEASE; MIL-100(FE); PLATFORM; SYSTEM;
D O I：
10.1007/s10934-018-0682-4
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Drug delivery carrier for targeted and controlled drug release is very important but challenging. In this work, a nano-sized metal-organic frameworks (MOFs)-based magnetic core-shell nanoparticles (NPs) has been designed for targeted drug delivery. Fe3O4@MIL-100(Fe) magnetic NPs were successfully prepared by a facile step-by-step assembly method. By the combination of the high porosity of MOFs shell and the magnetic characteristics of Fe3O4 core, making Fe3O4@MIL-100(Fe) magnetic NPs as an excellent drug delivery system. Significantly, the anti-inflammatory drug Ibuprofen (IBU) was effectively loaded on the magnetic NPs with a loading capacity of 0.31gg(-1), and it took as long as 70h to release IBU completely in PBS buffer solution at 37 degrees C. This work demonstrates that the nano-sized MOFs-based magnetic NPs are promising candidates for targeted drug delivery applications.
引用
收藏
页码：813 / 818
页数：6
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