Biomarkers for responses to heavy metals

被引：6
作者：
Ohsawa, M
机构：
[1] Faculty of Pharmaceutical Sciences, Teikyo University
[2] Dept. of Environmental Toxicology, Faculty of Pharmaceutical Sciences, Teikyo University, Suarashi, Sagamiko
来源：
CANCER CAUSES & CONTROL | 1997年 / 8卷 / 03期
关键词：
autoantibody; biomarker; cadmium; immunotoxicity; heavy metals;
D O I：
10.1023/A:1018473708846
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Biomarkers for pathophysiological responses to heavy metals are described with special reference to immunotoxic responses to them. Autoantibody induction in animals by exposure to cadmium is exemplified and discussed on its relevance to pathogenesis of cadmium-induced renal disease. The availability of autoantibodies as a mechanism-oriented biomarker is discussed further in association with cases of autoantibody induction in heavy metal workers.
引用
收藏
页码：514 / 517
页数：4
相关论文
共 31 条
[1]   SEARCH FOR ANTI-LAMININ ANTIBODIES IN THE SERUM OF WORKERS EXPOSED TO CADMIUM, MERCURY-VAPOR OR LEAD [J].
BERNARD, AM ;
ROELS, HR ;
FOIDART, JM ;
LAUWERYS, RL .
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH, 1987, 59 (03) :303-309
[2]  
BERNIER J, 1994, ENV HLTH PERSPECT S9, V103, P23
[3]   AUTOIMMUNITY AND HEAVY-METALS [J].
BIGAZZI, PE .
LUPUS, 1994, 3 (06) :449-453
[4]   CLONING, CHROMOSOMAL MAPPING AND CHARACTERIZATION OF THE HUMAN METAL-REGULATORY TRANSCRIPTION FACTOR MTF-1 [J].
BRUGNERA, E ;
GEORGIEV, O ;
RADTKE, F ;
HEUCHEL, R ;
BAKER, E ;
SUTHERLAND, GR ;
SCHAFFNER, W .
NUCLEIC ACIDS RESEARCH, 1994, 22 (15) :3167-3173
[5]  
CARDENAS A, 1993, BRIT J IND MED, V50, P17
[6]   CELLULAR ADAPTATION IN METAL TOXICOLOGY AND METALLOTHIONEIN [J].
CHERIAN, MG ;
NORDBERG, M .
TOXICOLOGY, 1983, 28 (1-2) :1-15
[7]   IMMUNOLOGICALLY MEDIATED GLOMERULONEPHRITIS INDUCED BY HEAVY-METALS [J].
DRUET, P ;
BERNARD, A ;
HIRSCH, F ;
WEENING, JJ ;
GENGOUX, P ;
MAHIEU, P ;
BIRKELAND, S .
ARCHIVES OF TOXICOLOGY, 1982, 50 (3-4) :187-194
[8]  
DRUET P, 1989, AUTOIMMUNITY TOXICOL, P347
[9]  
ELGAZZAR RM, 1994, TOXICOLOGIST, V14, P291
[10]  
EVANS HL, 1994, TOXICOLOGIST, V14, P291
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