HPLC determination of telmisartan in bulk and pharmaceutical formulations

A rapid and sensitive high performance liquid chromatographic method was developed for die estimation of telmisartan in pharmaceutical dosage forms. Telmisartan was chromatographed on a reverse phase C-18 column in a mobile phase consisting of methanol : acetonitrile : buffer (pH 2.8) in the ratio of 20: 70 : 10 v/v. The mobile phase was pumped at a flow rate of 1 mL/min and the eluents were monitored at 290 nm. The calibration curve was linear in the range of 10-1000 ng/mL. The intra- and inter-day variation was found to be less than 1% showing high precision of the assay method. The mean recovery of die drug from the solution containing 50 ng/mL was 96.6 +/- 1.13% indicating high accuracy of the proposed HPLC method. Due to its simplicity, rapidness, high precision and accuracy the proposed HPLC method may be used for determining telmisartan in bulk drug samples and pharmaceutical dosage forms.