Oxidative Stress-Induced Cellular Senescence in Aging Retina and Age-Related Macular Degeneration

被引：40

作者：

Terao, Ryo ^{[1
,2
]}

Ahmed, Tazbir ^{[1
]}

Suzumura, Ayana ^{[3
]}

Terasaki, Hiroko ^{[4
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Ophthalmol, Tokyo 1138654, Japan

[2] Washington Univ, Dept Ophthalmol & Visual Sci, Sch Med St Louis, St Louis, MO 63110 USA

[3] Nagoya Univ, Grad Sch Med, Dept Ophthalmol, Nagoya, Aichi 4668550, Japan

[4] Nagoya Univ, Inst Innovat Future Soc, Nagoya, Aichi 4648601, Japan

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 11期

关键词：

aging; age-related macular degeneration; cellular senescence; inflammation; oxidative stress; PIGMENT EPITHELIAL-CELLS; NF-KAPPA-B; MITOCHONDRIAL-DNA DAMAGE; SECRETORY PHENOTYPE; PREMATURE SENESCENCE; TUMOR-SUPPRESSOR; BETA-GALACTOSIDASE; ENDOTHELIAL-CELLS; EXPRESSION; ACTIVATION;

D O I：

10.3390/antiox11112189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cellular response characterized by cell cycle arrest. Cellular senescence is an important contributor to aging and age-related diseases through the alteration of cellular function and the secretion of senescence-associated secretory phenotypes. As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. In this review, we focused on the mechanism of oxidative stress-induced senescence in retinal cells and its role in the pathogenesis of AMD.

引用

页数：16

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