Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer

被引：108

作者：

Jin, Xiao ^{[1
]}

Dai, Lu ^{[1
]}

Ma, Yilan ^{[1
]}

Wang, Jiayan ^{[1
]}

Liu, Zheng ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 2, Med Ctr Digest Dis, 121 Jiangjiayuan Rd, Nanjing 210011, Jiangsu, Peoples R China

来源：

CANCER CELL INTERNATIONAL | 2020年 / 20卷 / 01期

关键词：

Hypoxia; HIF-1; alpha; Pancreatic cancer; Tumorigenesis; Progression; Review; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; EPITHELIAL-MESENCHYMAL TRANSITION; FACTOR-I; UP-REGULATION; GEMCITABINE RESISTANCE; GLUCOSE-METABOLISM; COLORECTAL-CANCER; INDUCED AUTOPHAGY; TUMOR-GROWTH; EXPRESSION;

D O I：

10.1186/s12935-020-01370-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen-deficient tumor microenvironment. Numerous studies revealed the central role of HIF-1 alpha in the carcinogenesis and progression of pancreatic cancer. This article reviewed the molecular mechanisms of how HIF-1 alpha regulated tumorigenesis and progression of pancreatic cancer and suggested that targeting HIF-1 alpha and its signaling pathways could be promising therapeutics for pancreatic cancer.

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页数：11

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