Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer

被引:108
作者
Jin, Xiao [1 ]
Dai, Lu [1 ]
Ma, Yilan [1 ]
Wang, Jiayan [1 ]
Liu, Zheng [1 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 2, Med Ctr Digest Dis, 121 Jiangjiayuan Rd, Nanjing 210011, Jiangsu, Peoples R China
关键词
Hypoxia; HIF-1; alpha; Pancreatic cancer; Tumorigenesis; Progression; Review; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; EPITHELIAL-MESENCHYMAL TRANSITION; FACTOR-I; UP-REGULATION; GEMCITABINE RESISTANCE; GLUCOSE-METABOLISM; COLORECTAL-CANCER; INDUCED AUTOPHAGY; TUMOR-GROWTH; EXPRESSION;
D O I
10.1186/s12935-020-01370-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen-deficient tumor microenvironment. Numerous studies revealed the central role of HIF-1 alpha in the carcinogenesis and progression of pancreatic cancer. This article reviewed the molecular mechanisms of how HIF-1 alpha regulated tumorigenesis and progression of pancreatic cancer and suggested that targeting HIF-1 alpha and its signaling pathways could be promising therapeutics for pancreatic cancer.
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页数:11
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