Biogenic gold nanoparticles against wild and resistant type visceral leishmaniasis

被引：6

作者：

Das, Suvadra ^{[1
]}

Halder, Asim ^{[1
]}

Roy, Partha ^{[2
]}

Mukherjee, Arup ^{[1
]}

机构：

[1] Univ Calcutta, Dept Chem Technol, 92 APC Rd, Kolkata 700009, W Bengal, India

[2] Adamas Univ, Dept Pharmaceut Technol, Kolkata 700126, W Bengal, India

来源：

MATERIALS TODAY-PROCEEDINGS | 2018年 / 5卷 / 01期

关键词：

Gallic acid; gold nanoparticle; visceral leishmaniasis; polyphenols; GALLIC ACID; DRUG-DELIVERY; ANTIOXIDANT; APOPTOSIS; LIPOSOMES; CURCUMIN; SYSTEMS; CELLS;

D O I：

10.1016/j.matpr.2018.01.086

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Leishmaniasis is a WHO notified neglected tropical disease and the lethal visceral leishmaniasis variant is endemic in Indian subcontinent. Gold nanoparticles (Aunp) have emerged as veritable tools in drug delivery because of their higher residence time in systemic circulation compared to other nanocarriers. Polyphenolic compound Gallic acid is used for bio-rated synthesis and in situ functionalization for GAunp. Synthesized nanoparticle exhibited surface plasmon response at 530nm and zeta potential of -8.53 mV. The average size of particles in TEM was 12.05 nm. XRD and SAED definite fcc crystalline structure of metallic gold particles and FTIR confirmed gallic acid bioconjugation. Antileishmanial efficiency of GAunp was established against wild type (IC50 4 +/- 1), sodium stibogluconate resistant strain(IC50 4.5 +/- 2). Macrophage uptake of GAunp was complete within one hour as studied in TEM experiments. (c) 2018 Elsevier Ltd. All rights reserved.

引用

页码：2912 / 2920

页数：9

共 22 条

[1]

[Anonymous], 2002, WORLD HLTH REP

[2] Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages [J].

Arnida ;

Janat-Amsbury, M. M. ;

Ray, A. ;

Peterson, C. M. ;

Ghandehari, H. .

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2011, 77 (03) :417-423

[3] Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity [J].

Boisselier, Elodie ;

Astruc, Didier .

CHEMICAL SOCIETY REVIEWS, 2009, 38 (06) :1759-1782

[4] HUMAN CUTANEOUS LEISHMANIA IN A MOUSE MACROPHAGE LINE - PROPAGATION AND ISOLATION OF INTRACELLULAR PARASITES [J].

CHANG, KP .

SCIENCE, 1980, 209 (4462) :1240-1242

[5] Therapeutic potential of nanoparticulate systems for macrophage targeting [J].

Chellat, F ;

Merhi, Y ;

Moreau, A ;

Yahia, L .

BIOMATERIALS, 2005, 26 (35) :7260-7275

[6] Gallic acid, a major component of Toona sinensis leaf extracts, contains a ROS-mediated anti-cancer activity in human prostate cancer cells [J].

Chen, Huei-Mei ;

Wu, Yang-Chang ;

Chia, Yi-Chen ;

Chang, Fang-Rong ;

Hsu, Hseng-Kuang ;

Hsieh, Ya-Ching ;

Chen, Chih-Chen ;

Yuan, Shyng-Shiou .

CANCER LETTERS, 2009, 286 (02) :161-171

[7] Parasitic diseases: Liposomes and polymeric nanoparticles versus lipid nanoparticles [J].

Date, Abhijit A. ;

Joshi, Medha D. ;

Patravale, Vandana B. .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (06) :505-521

[8] Generation of Leishmania donovani axenic amastigotes:: their growth and biological characteristics [J].

Debrabant, A ;

Joshi, MB ;

Pimenta, PFP ;

Dwyer, DM .

INTERNATIONAL JOURNAL FOR PARASITOLOGY, 2004, 34 (02) :205-217

[9] Size matters: gold nanoparticles in targeted cancer drug delivery [J].

Dreaden, Erik C. ;

Austin, Lauren A. ;

Mackey, Megan A. ;

El-Sayed, Mostafa A. .

THERAPEUTIC DELIVERY, 2012, 3 (04) :457-478

[10]

Faried A, 2007, INT J ONCOL, V30, P605

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