Synthesis and biological evaluation of 4β-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxins as potential anticancer agents

被引：17
|
作者：
Reddy, Pitta Bhaskar [1 ]
Agrawal, Satyam Kumar [2 ]
Singh, Swaran [1 ]
Bhat, Bilal A. [1 ]
Saxena, Ajit K. [2 ]
Kumar, Halmuthur M. Sampath [1 ]
Qazi, Gulam N. [1 ]
机构：
[1] Indian Inst Integrat Med, Dept Synthet Chem, Jammu 180001, India
[2] Indian Inst Integrat Med, Dept Pharmacol, Jammu 180001, India
来源：
CHEMISTRY & BIODIVERSITY | 2008年 / 5卷 / 09期
关键词：
D O I：
10.1002/cbdv.200890168
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of novel 4 beta-[(4-substituted)-1,2,3-triazol-1-yl]podophyllotoxin derivatives were synthesized by employing Cu-1-catalyzed click chemistry and evaluated for their anticancer activity against a panel of seven human cancer cell lines (HT-29, HCT-15, 502713, HOP-62, A-549, MCF-7, and SF-295). The compounds 9b, 9c, 9c, 9f, and 9h showed significant cytotoxic activities especially against HT-29, HCT-15, 502713, cell lines.
引用
收藏
页码：1792 / 1802
页数：11
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